Anatomical and chemical studies of a nigro-neostriatal projection in the cat.
Anatomical and chemical studies of a nigro-neostriatal projection in the cat.
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猫黑质新纹状体投射的解剖学和化学研究。
DOI：
10.1016/0006-8993(71)90009-6
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发表时间：
1971
期刊：
影响因子：
2.9
通讯作者：
Alfred Heller
中科院分区：
文献类型：
--
作者：
Ribert Y. Moore;Ranbir K. Bhatnagar;Alfred Heller
现在有相当多的证据表明，产生多巴胺的神经元从黑质直接投射到新纹状体。这种预测的第一个证据来自观察到的明显退行性变的黑质后，破坏neostriatumZ 7，41。最近，应用的Falck-Hillarp荧光组织化学方法23，24已允许演示的多巴胺含细胞体在黑质zl和多巴胺含终端的neostriatum 4，16，80。而且，尽管使用这种方法尚未清楚地显示黑质和新纹状体之间的通路，但细胞体和终末的分布表明存在这样的通路。这一途径的进一步证据由两条证据线提供。首先，黑质和腹侧中脑被盖或沿着内囊的黑质喙部的病变使新纹状体多巴胺2，a，~，7，z6，35，44，46，47显著降低，表明病变破坏了支配新纹状体的多巴胺产生神经元的轴突。第二，正常情况下在新纹状体16中发现的高浓度多巴胺在帕金森病患者的大脑中大大减少，这与黑质a4的显著细胞损失有关。尽管有这些证据，但仍无法通过常规解剖技术证明黑质-新纹状体投射17，18，4s，电生理学研究也未获得直接通路的明确数据19，29，40。本研究提供了一个解剖演示的过程和终止的黑质-新纹状体的投影和进一步的化学证据表明，神经元的投影多巴胺生产。
There is now considerable evidence for a direct projection of dopamine-producing neurons from the substantia nigra to the neostriatum. The first evidence for such a projection came from observations of apparent retrograde degeneration in the substantia nigra following destruction of the neostriatumZ7, 41. More recently, application of the Falck-Hillarp fluorescence histochemical method23, 24 has permitted demonstration of dopamine-containing cell bodies in the substantia nigra zl and dopamine-containing terminals in the neostriatum4, 16, 80. And, although a pathway between the substantia nigra and neostriatum has not been clearly shown using this method, the distribution of the cell bodies and terminals suggests that such a pathway exists. Further evidence for the pathway is provided by two lines of evidence. First, lesions in the substantia nigra and rostral to it in the ventral midbrain tegmentum or along the internal capsule produce marked decreases in neostriatal dopamine 2, a,~, 7, z6, 35, 44, 46, 47, suggesting that the lesions have destroyed the axons of dopamine-producing neurons innervating the neostriatum. Second, the high concentration of dopamine normally found in the neostriatum 16 is greatly reduced in the brains of parkinsonian patients2Z, as in association with a marked cell loss from the substantia nigra a4. Despite this evidence, it has not been possible to demonstrate a nigro-neostriatal projection by conventional anatomical techniques17, 18, 4s, and electrophysiologic studies have not yielded definitive data19, 29, 40 for a direct pathway. The present study provides an anatomical demonstration of the course and termination of a nigro-neostriatal projection and further chemical evidence that neurons of the projection are dopamine-producing.