The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications.
The highly compact structure of the mitochondrial DNA polymerase genomic region of Drosophila melanogaster: functional and evolutionary implications.
复制标题
果蝇线粒体 DNA 聚合酶基因组区域的高度紧凑结构：功能和进化意义。
DOI：
10.1046/j.1365-2583.2000.00191.x
复制
发表时间：
2000
影响因子：
2.6
通讯作者：
Garesse,R
中科院分区：
文献类型：
--
作者：
Lefai,E;Fernández-Moreno,MA;Kaguni,LS;Garesse,R
黑腹果蝇基因组区包含5个紧密聚集的基因，其结构已被确定，并就其功能和进化关系进行了评估。除了编码线粒体DNA复制的关键酶DNA聚合酶γ全酶的两个亚基（α和β）的基因外，该簇中包含的其他基因也可能参与线粒体的细胞分布以及线粒体和核DNA复制的协调。基因簇非常紧凑，基因间空间很小。它包含两个双向启动子区域，特别值得注意的是在它的两个基因中检测到的5 '端重叠，这在原核和真核生物基因组组织中都是一种特殊的情况。
The structure of aDrosophila melanogastergenomic region containing five tightly clustered genes has been determined and evaluated with regard to its functional and evolutionary relationships. In addition to the genes encoding the two subunits (α and β) of the DNA polymerase γ holoenzyme, the key enzyme for mitochondrial DNA replication, other genes contained in the cluster may be also involved in the cellular distribution of mitochondria and in the coordination of mitochondrial and nuclear DNA replication. The gene cluster is extremely compact, with very little intergenic space. It contains two bidirectional promoter regions, and particularly notable is the 5′ end overlap detected in two of its genes, an exceptional situation in both prokaryotic and eukaryotic genome organization.