The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy.
The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy.
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DOI：
10.1111/j.1365-2796.2010.02321.x
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发表时间：
2011-01
影响因子：
11.1
通讯作者：
Tracey KJ
中科院分区：
文献类型：
--
作者：
Huston JM;Tracey KJ
以肿瘤坏死因子、白介素1和白介素6为靶点的生物疗法被广泛用于治疗类风湿性关节炎、炎症性肠病和越来越多的其他症状，通常取得了显著的成功。现在，神经科学的进步与这种治疗方法发生了冲突，可能会使开发神经刺激器来抑制细胞因子成为可能。在迷走神经中传递的动作电位最终导致乙酰胆碱的释放，从而阻止表达乙酰胆碱受体的细胞产生细胞因子。这种胆碱能抗炎途径的分子机制可归因于烟碱α7乙酰胆碱受体亚单位的信号转导，该亚单位是控制细胞因子转录和翻译的细胞内信号调节因子。有利的临床前数据支持这样一种可能性，即有可能在未来的治疗性医疗设施中增加神经刺激剂，可能取代一些抑制细胞因子的药物。
Biological therapeutics targeting TNF, IL-1, and IL-6 are widely used for treatment of rheumatoid arthritis, inflammatory bowel disease, and a growing list of other syndromes, often with remarkable success. Now advances in neuroscience have collided with this therapeutic approach, perhaps rendering possible the development of nerve stimulators to inhibit cytokines. Action potentials transmitted in the vagus nerve culminate in the release of acetylcholine that blocks cytokine production by cells expressing acetylcholine receptors. The molecular mechanism of this cholinergic antiinflammatory pathway is attributable to signal transduction by the nicotinic alpha 7 acetylcholine receptor subunit, a regulator of the intracellular signals that control cytokine transcription and translation. Favorable preclinical data support the possibility that it may be possible to add nerve stimulators to the future therapeutic armamentarium, possibly replacing some drugs to inhibit cytokines.