NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.
NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.
复制标题
NHERF 和肾钠氢交换器 NHE3 的调节。
DOI：
10.1007/s00424-005-1384-8
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Shenolikar,Shirish
中科院分区：
文献类型：
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作者：
Weinman,EdwardJ;Cunningham,Rochelle;Shenolikar,Shirish
钠氢交换器3（NHE 3）亚型是肾脏近曲小管中主要的受调节钠转运蛋白。通过激素刺激调节NHE 3的研究已经鉴定了许多PDZ衔接蛋白，其形成顶端/亚顶端膜支架，该支架结合NHE 3并促进其活性响应于cAMP和蛋白激酶A的活化而下调。近端小管衔接蛋白如钠-氢交换调节因子-1（NHERF-1）、NHERF-2和PDZ结构域蛋白-1（PDZK 1）彼此之间以及与蛋白质靶点如NHE 3之间的精确关系随着特异性试剂和遗传改变动物的发展而不断发展。在这篇综述中，我们跟踪NHERF-1和NHERF-2的发现，并更新我们目前对这些蛋白质与NHE 3的调控和运输之间的关系的理解。
The sodium-hydrogen exchanger 3 (NHE3) isoform is the major regulated sodium transporter in the proximal convoluted tubule of the kidney. Study of the regulation of NHE3 by hormonal stimuli has identified a number of PDZ adaptor proteins that form an apical/subapical membrane scaffold that binds NHE3 and facilitates down-regulation of its activity in response to cAMP and activation of protein kinase A. The precise relation of proximal tubule adaptor proteins such as sodium-hydrogen exchanger regulatory factor-1 (NHERF-1), NHERF-2, and PDZ domain-containing-protein-1 (PDZK1) with each other and with protein targets such as NHE3 has been evolving with the development of specific reagents and genetically altered animals. In this review, we trace the discovery of NHERF-1 and NHERF-2, and update our current understanding of the relation between these proteins and the regulation and trafficking of NHE3.