Tracks to therapy
Tracks to therapy
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DOI：
10.1016/s1350-4487(99)00098-0
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发表时间：
1999-06-01
影响因子：
2
通讯作者：
Cucinotta, FA
中科院分区：
文献类型：
--
作者：
Katz, R;Cucinotta, FA
对粒子径迹结构的研究导致了基于径向剂量和放射生物学靶理论的径迹效应模型，这些模型在描述和预测物理、化学和生物系统中的径迹效应方面非常成功。为了描述哺乳动物细胞失活，需要两种失活模式，称为γ-杀死和离子-杀死，第一种是由于来自相邻离子路径的δ射线的协同效应，因此类似于来自γ射线的效应，第二种是单个离子通过细胞核的效应。离子杀伤效应更严重，其中经历离子杀伤的细胞分数导致氧增强比的降低和相对生物有效性的增加，但这些都伴随着修复的损失，因此导致高LET治疗中分馏效率的降低，如我们对“展开布拉格峰”中的放射生物学效应的计算所示。
Studies of the structure of particle tracks have led to models of track effects based on radial dose and radiobiological target theory that have been very successful in describing and predicting track effects in physical, chemical, and biological systems. For describing mammalian cellular inactivation two inactivation modes are required, called gamma-kill and ion-kill, the first due to synergistic effects of delta rays from adjacent ion paths thus resembling the effects from gamma rays, and the second to the effects of single ion transits through a cell nucleus. The ion-kill effect is more severe, where the fraction of cells experiencing ion kill is responsible for a decrease in the oxygen enhancement ratio, and an increase in relative biological effectiveness, but these are accompanied by loss of repair, hence to a reduction in the efficiency of fractionation in high LET therapy, as shown by our calculations for radiobiological effects in the "spread out Bragg Peak".