Persistent Minority K103N Mutations among Women Exposed to Single-Dose Nevirapine and Virologic Response to Nonnucleoside Reverse-Transcriptase Inhibitor-Based Therapy
Persistent Minority K103N Mutations among Women Exposed to Single-Dose Nevirapine and Virologic Response to Nonnucleoside Reverse-Transcriptase Inhibitor-Based Therapy
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DOI：
10.1086/596486
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发表时间：
2009-02-15
影响因子：
11.8
通讯作者：
Kuhn, Louise
中科院分区：
文献类型：
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作者：
Coovadia, Ashraf;Hunt, Gillian;Kuhn, Louise
Objective.我们研究了在人类免疫缺陷病毒（HIV）感染的女性中，单剂量奈韦拉平（sdNVP）治疗对非核苷类逆转录酶抑制剂（NNRTI）治疗的病毒学应答是否有长期影响。在南非约翰内斯堡进行了一项观察性流行病学研究。在94名18-36个月前接受sdNVP的HIV感染女性和60名12-36个月前怀孕的未暴露的HIV感染女性之间比较了对基于NNRTI的治疗的初始和持续病毒学应答。每4周一次测量病毒载量，直至第24周，然后每12周一次，直至第78周。至病毒抑制的时间（病毒载量，
Objective. We investigated whether there are long-lasting effects of exposure to single-dose nevirapine (sdNVP) treatment on virologic response to nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based therapy among human immunodeficiency virus (HIV)-infected women.Methods. An observational epidemiologic study was conducted in Johannesburg, South Africa. Initial and sustained virologic response to NNRTI-based therapy was compared between 94 HIV-infected women who had received sdNVP 18-36 months earlier and 60 unexposed, HIV-infected women who had been pregnant 12-36 months earlier. Viral load was measured every 4 weeks up to week 24 and then every 12 weeks up to week 78. Time to viral suppression (viral load,