Targeting of neutrophil activation in the early phase of the disease for prevention of Coronavirus disease‐19 severity
Targeting of neutrophil activation in the early phase of the disease for prevention of Coronavirus disease‐19 severity
复制标题
DOI：
10.1111/1348-0421.12978
复制
发表时间：
2022-03
影响因子：
2.6
通讯作者：
F. Sendo;H. Yoshitake;Y. Araki
中科院分区：
文献类型：
--
作者：
F. Sendo;H. Yoshitake;Y. Araki
预防疾病的严重程度似乎对降低冠状病毒（CoV）疾病的死亡率至关重要。中性粒细胞在诱发严重程度中起关键作用。这里提出，抑制中性粒细胞活化和/或补体级联反应，导致这种细胞在疾病的早期阶段活化，是抑制疾病恶化的潜在工具。下文强调了干预的适当时机的必要性。(1)在严重急性呼吸综合征-CoV-2感染的极早期阶段进行干预可能会损害宿主对感染的防御反应，因为中性粒细胞在这种反应中起着关键作用，（2）在太晚的阶段进行干预不会阻止完全活化的中性粒细胞的浸润，这些中性粒细胞会产生大量有毒物质。
The prevention of the disease severity seems critical for reducing the mortality of Coronavirus (CoV) disease‐19. The neutrophils play a key role in the induction of severity. It is proposed here that inhibition of neutrophil activation and/or cascade reactions of complement, leading to this cell activation at the early phase of the disease, is a potential tool to inhibit aggravation of the disease. The need for appropriate timing in intervention is emphasized as follows. (1) Intervention at the very early stage of severe acute respiratory syndrome‐CoV‐2 infection may harm the defensive host response to the infection because of the critical function of neutrophils in this response, and (2) intervention at too late a stage will not stop the infiltration of fully activated neutrophils that produce large amounts of toxic substances.