After BRCA1 and BRCA2-what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer
After BRCA1 and BRCA2-what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer
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DOI：
10.1086/318187
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发表时间：
2001-02-01
影响因子：
9.8
通讯作者：
Hopper, JL
中科院分区：
文献类型：
--
作者：
Cui, JS;Antoniou, AC;Hopper, JL
BRCA1和BRCA2的突变导致女性乳腺癌的显性遗传高风险，似乎只能解释疾病聚集的一小部分。为了研究可能的额外遗传成分，我们进行了单位点和双位点分离分析，有和没有多基因背景，使用三代家庭，通过858名年龄诊断为乳腺癌的妇女确定。
Mutations in BRCA1 and BRCA2 that cause a dominantly inherited high risk of female breast cancer seem to explain only a small proportion of the aggregation of the disease. To study the possible additional genetic components, we conducted single-locus and two-locus segregation analyses, with and without a polygenic background, using three-generation families ascertained through 858 women with breast cancer diagnosed at age