Age-related resting-state functional connectivity in the olfactory and trigeminal networks.
Age-related resting-state functional connectivity in the olfactory and trigeminal networks.
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DOI：
10.1097/wnr.0000000000000850
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发表时间：
2017-10-18
期刊：
影响因子：
1.7
通讯作者：
Yang QX
中科院分区：
文献类型：
--
作者：
Karunanayaka P;Tobia MJ;Yang QX
鼻内化学感觉的大脑网络已被证明在人类中是内在组织的。然而，很少有人知道如何在化学感觉网络的内在功能连接（FC）的变化与衰老有关。因此，我们研究了年龄对嗅觉和三叉神经网络（ON和TN）静息状态功能连接的影响，方法是将两个免费获得的静息状态fMRI数据集（从NITRC.org获得;亚特兰大和纽约）与我们实验室收集的数据相结合，以产生一个大样本量（N=103; 51名女性），年龄范围为20-61岁。在激活研究和荟萃分析中，使用锚嗅觉和三叉神经网络的MNI坐标定义种子区域。嗅觉网络（ON）包括梨状皮质和眶额皮质。三叉神经网络（TN）包括前额叶皮质和扣带回皮质。在组水平分析中，扫描部位、性别和年龄被用作协变量。ON与海马旁回之间的FC与年龄呈负相关。TN与海马旁回的FC呈正相关。同样，年龄与腹侧纹状体的ON FC和默认模式网络（DMN）的TN FC呈正相关。这些结果反映了人类化学感觉系统内在FC的不同年龄相关的改变。
Brain networks for intranasal chemosensation have been shown to be intrinsically organized in humans. However, little is known about how changes in the intrinsic functional connectivity (FC) in chemosensory networks are related to aging. We, therefore, investigated the impact of age on resting state functional connectivity in the olfactory and trigeminal networks (ON and TN) by combining two freely available resting state fMRI data sets (obtained from the NITRC.org; Atlanta and New York) with data collected in our lab to generate a large sample size (N=103; 51 females) spanning the age range of 20–61 years. Seed regions were defined using MNI coordinates that anchor olfactory and trigeminal networks in activation studies and meta-analyses. The olfactory network (ON) included the piriform cortex and oribtofrontal cortex. The trigeminal network (TN) included the anterior insula and cingulate cortex. Scanner site, sex, and age were used as covariates in group level analyses. The FC between the ON and parahippocampal gyrus was negatively correlated with age. The FC between the TN and parahippocampal gyrus, however, was positively correlated. Similarly, age was positively correlated with the ON FC to the ventral striatum, and the TN FC to the default mode network (DMN). These results reflect divergent age-related alterations of the intrinsic FC of the human chemosensory system.