Halothane solubility in human blood.
Halothane solubility in human blood.
复制标题
氟烷在人体血液中的溶解度。
DOI：
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发表时间：
1977
影响因子：
9.8
通讯作者：
W. Mapleson
中科院分区：
文献类型：
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作者：
R. Saraiva;B. Willis;A. Steward;J. Lunn;W. Mapleson
在营养状况对氟烷麻醉影响的研究中，获得的结果显示了20名接受择期手术的患者氟烷的血/气分配系数如何随血液化学而变化。对于每个患者，通过在37 ℃下用1%氟烷在5%二氧化碳中的空气混合物平衡血液样品，然后进行化学提取并通过气相色谱法估计氟烷含量来测量分配系数λ。通过常规实验室方法测量红细胞压积和血红蛋白、血清白蛋白、总蛋白、甘油三酯和胆固醇浓度。寻求回归的λ对每一个这些，球蛋白浓度和白蛋白：球蛋白和白蛋白：总蛋白的比例，推导出这些测定。唯一具有统计学意义的回归（P = 0.0004）是λ对血清甘油三酯浓度（T）（mmol/L）的回归：λ = 1.83 + 0.424 T。λ对血红蛋白浓度的依赖性没有统计学意义，但回归的斜率与以前的研究者一致。λ（校正为平均甘油三酯浓度）对白蛋白：球蛋白和白蛋白：总蛋白比值的回归无统计学显著性，但与早期报告的结果无显著差异。
In a study of the influence of nutritional state on halothane anaesthesia, results were obtained which showed how the blood/gas partition coefficient for halothane varied with blood chemistry in 20 patients undergoing elective surgery. For each patient the partition coefficient lambda was measured by equilibration at 37 degrees C of a blood sample with a 1% halothane in 5% carbon dioxide in air mixture, followed by chemical extraction and estimation of the halothane content by gas chromatography. The haematocrit and haemoglobin, serum albumin, total protein, triglyceride and cholesterol concentrations were measured by routine laboratory methods. Regressions were sought of lambda on each of these, and on the globulin concentration and the ratios of albumin: globulin and albumin: total protein, deduced from these determinations. The only statistically significant regression (P = 0.0004) was that of lambda on the serum triglyceride concentration (T) (mmol/litre): lambda = 1.83 + 0.424T. The dependence of lambda on haemoglobin concentration was not statistically significant, but the slope of the regression was consistent with those of previous investigators. The regressions of lambda, corrected to the mean triglyceride concentration, on the ratios of albumin: globulin and albumin: total protein were not statistically significant but were not significantly different from an earlier reported result.