Neutrophils: game changers in glomerulonephritis?
Neutrophils: game changers in glomerulonephritis?
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DOI：
10.1016/j.molmed.2010.06.002
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发表时间：
2010-08
影响因子：
13.6
通讯作者：
Sethi S
中科院分区：
文献类型：
--
作者：
Mayadas TN;Rosetti F;Ernandez T;Sethi S
肾小球肾炎代表了一系列不同的疾病，这些疾病具有共同的免疫细胞介导的效应机制，导致器官损伤。中性粒细胞在增生性肾小球肾炎（GN）发病机制中的作用尚未得到充分认识。大多数人将中性粒细胞等同于杀死病原体并在急性炎症期间引起附带组织损伤。然而，这些吞噬细胞被赋予了传统上为适应性免疫系统的细胞保留的额外特征。它们与其他细胞交流，在反应中表现出可塑性，并有可能协调和通知随后的免疫反应，从而反驳它们到达，破坏然后消失的概念。因此，首先到达炎症部位的中性粒细胞是GN中潜在的游戏规则改变者。
Glomerulonephritides represent a diverse array of diseases that have in common immune cell-mediated effector mechanisms that cause organ damage. The contribution of neutrophils to the pathogenesis of proliferative glomerulonephritis (GN) is not well recognized. Most equate neutrophils with killing pathogens and causing collateral tissue damage during acute inflammation. However, these phagocytes are endowed with additional characteristics that have been traditionally reserved for cells of the adaptive immune system. They communicate with other cells, exhibit plasticity in their responses and have the potential to coordinate and inform the subsequent immune response, thus countering the notion that they arrive, destroy and then disappear. Therefore, neutrophils, which are the first to arrive at a site of inflammation, are potential game changers in GN.
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影响因子：
5.1
作者：
Bagavant H;Fu SM
通讯作者：
Fu SM
影响因子：
5.4
作者：
Aleman, Mercedes;de la Barrera, Silvia;Sasiain, Maria
通讯作者：
Sasiain, Maria
DOI：
10.1124/jpet.106.109058
发表时间：
2006-12-01
影响因子：
3.5
作者：
Braselmann, Sylvia;Taylor, Vanessa;Masuda, Esteban S.
通讯作者：
Masuda, Esteban S.
影响因子：
4.4
作者：
Byrne, A;Reen, DJ
通讯作者：
Reen, DJ
影响因子：
15.3
作者：
Cai, TQ;Wright, SD
通讯作者：
Wright, SD