WNT-4 EXPRESSION INDUCES A PREGNANCY-LIKE GROWTH-PATTERN IN RECONSTITUTED MAMMARY-GLANDS IN VIRGIN MICE
WNT-4 EXPRESSION INDUCES A PREGNANCY-LIKE GROWTH-PATTERN IN RECONSTITUTED MAMMARY-GLANDS IN VIRGIN MICE
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DOI：
10.1006/dbio.1995.1236
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发表时间：
1995-08-01
影响因子：
2.7
通讯作者：
DALE, TC
中科院分区：
文献类型：
--
作者：
BRADBURY, JM;EDWARDS, PAW;DALE, TC
WNT-4是WNT基因家族中的一员，在小鼠乳腺中的表达是在妊娠早期诱导的。为了研究WNT-4的功能，我们用重组逆转录病毒在处女动物的移植乳腺上皮中构件性表达WNT-4基因。在完全生长的腺体中，Wnt-4的表达导致导管比正常更高的分支，并导致一些肺泡的过早发育。这些变化与妊娠期间的变化相似，表明内源性Wnt-4的表达可能调节怀孕早期的上皮分支。小鼠乳腺肿瘤病毒激活的WITT基因家族成员之一WNT-4表达所诱导的修饰生长模式与WNT-1相似。由于WNT-1不在乳腺中正常表达，它可能通过激活WNT-4正常调控的发育途径而对乳腺发挥作用。(C)1995年学术出版社。
Expression of Wnt-4 a member of the Wnt gene family, is induced during early pregnancy in the mouse mammary gland. To investigate the function of Wnt-4, we used a recombinant retrovirus to constitutively express the gene in transplanted mammary epithelium grown in virgin animals. In fully grown glands, Wnt-4 expression resulted in ducts that were more highly branched than normal and caused some premature alveolar development. These changes resembled those seen during pregnancy, suggesting that endogenous Wnt-4 expression may regulate epithelial branching in early pregnancy. The modified growth pattern induced by Wnt-4 expression was similar to that induced by Wnt-1, one of the members of the Witt gene family activated by mouse mammary tumour virus. As Wnt-1 is not normally expressed in the mammary gland, it may exert its effect on the mammary gland by activating a developmental pathway normally regulated by Wnt-4. (C) 1995 Academic Press, Inc.