Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori:: possible association with p16 hypermethylation
Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori:: possible association with p16 hypermethylation
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DOI：
10.1007/s535-002-8127-8
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发表时间：
2002-01-01
影响因子：
6.3
通讯作者：
Kim, CY
中科院分区：
文献类型：
--
作者：
Kim, YS;Kim, JS;Kim, CY
背景。许多报告指出，治愈幽门螺杆菌感染可以诱导低度胃粘膜相关淋巴组织（MALT）淋巴瘤的完全缓解。尽管 p16 高甲基化在 MALT 淋巴瘤中常见，但这一发现与 MALT 淋巴瘤缓解之间的关联尚未阐明。我们进行了一项前瞻性研究来评估低度胃 MALT 淋巴瘤患者的预后和 p16 高甲基化的表达。方法。我们前瞻性地招募了 20 名幽门螺杆菌阳性低级别胃 MALT 淋巴瘤（I E-1 期）患者。消灭If后。幽门螺杆菌感染后，定期对患者进行内窥镜和组织学评估随访。采用甲基化特异性聚合酶链式反应（PCR）（MSP）方法连续检测p16高甲基化。结果。 18 名患者 (90%) 获得完全缓解，中位持续时间为 15.7 个月。 p16 高甲基化的初始检出率为 58%（成功评估 p16 高甲基化的 12 名患者中有 7 名）。在一项系列调查中，对 3 名患者进行了中位 28 个月的随访，结果显示 p16 高甲基化已经消失。结论。低级别胃MALT淋巴瘤根除H pylori感染后完全缓解可维持1年以上。需要进一步的研究来探讨 p16 高甲基化在胃 MALT 淋巴瘤发病机制中的作用。
Background. Many reports have stated that the cure of Helicobacter pylori infection can induce a complete remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although p16 hypermethylation was frequently found in MALT lymphoma, the association between this finding and the remission of MALT lymphoma has not been clarified. We performed a prospective study to evaluate the outcome of patients with low-grade gastric MALT lymphoma and the expression of p16 hypermethylation. Methods. We prospectively enrolled 20 patients with H. pylori-positive low-grade gastric MALT lymphoma (stage I E-1). After the eradication of If. pylori, the patients were regularly followed-up with endoscopic and histological assessment. The methylation-specific polymerase chain reaction (PCR) (MSP) method was used for the serial detection of p16 hypermethylation. Results. Eighteen patients (90%) achieved complete remission, with a median duration of 15.7 months. The initial detection rate of p16 hypermethylation was 58% (7 of the 12 patients in whom p16 hypermethylation was evaluated successfully). In a serial investigation, 3 patients who were followed-up for a median 28 months showed that the p16 hypermethylation had disappeared. Conclusions. Complete remission of low-grade gastric MALT lymphoma after the eradication of H pylori infection can be maintained for more than 1 year. Further studies are warranted to investigate the role of p16 hypermethylation in the pathogenesis of gastric MALT lymphoma.