Dietary precursors of trimethylamine in man: A pilot study
Dietary precursors of trimethylamine in man: A pilot study
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DOI：
10.1016/s0278-6915(99)00028-9
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发表时间：
1999-05-01
影响因子：
4.3
通讯作者：
Smith, RL
中科院分区：
文献类型：
--
作者：
Zhang, AQ;Mitchell, SC;Smith, RL
在口服（15 mmol）胆碱（63%剂量为三甲胺及其n -氧化物）、D、左肉碱（31%剂量）和三甲胺n -氧化物（78%剂量）后，观察到男性三甲胺及其n -氧化物的尿排泄增加。类似的摄入甜菜碱、肌酐或卵磷脂没有引起任何显著的增加。在调查的46种不同食物中，只有鱼和其他海产品显著增加了尿三甲胺和n -氧化物。摄入水果、蔬菜、谷物、奶制品和肉类没有可测量的影响。给出了以前被认为是前体的食物明显缺乏三甲胺供应的原因，并强调了肠道菌群的作用。1999爱思唯尔科学有限公司阿里版权所有。
An increased urinary excretion of trimethylamine and its Ai-oxide were observed in man following the oral intake (15 mmol) of choline (63% dose as trimethylamine and its N-oxide), D,L-carnitine (31% dose) and trimethylamine N-oxide (78% dose). Similar ingestion of betaine, creatinine or lecithin failed to elicit any significant increases. Of 46 different foods investigated, only fish and other sea-products gave rise to significant increases in urinary trimethylamine and N-oxide. Ingestion of fruits, vegetables, cereal and dairy produce, and meats had no measurable effects. Reasons for the apparent lack of trimethylamine provision by foods previously thought to be precursors are given and the role of gut microflora highlighted. (C) 1999 Elsevier Science Ltd. Ali rights reserved.