Transvascular albumin and IgG flux in skin after a continuous 3-h bradykinin infusion.
Transvascular albumin and IgG flux in skin after a continuous 3-h bradykinin infusion.
复制标题
连续 3 小时缓激肽输注后，经血管白蛋白和 IgG 在皮肤中流动。
DOI：
10.1152/ajpheart.1992.263.4.h1064
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Bell,DR
中科院分区：
文献类型：
--
作者：
Wallace,JR;Bell,DR
将缓激肽（1微克/分钟）注入麻醉兔的一只后腿股动脉3小时，测量标记白蛋白和免疫球蛋白（Ig） G的初始血管外摄取与内源性白蛋白和IgG的淋巴蛋白通量进行比较。使用缓激肽时，白蛋白和IgG的初始血管外摄取（以血浆浓度下1小时血管外分布空间除以时间计算，并用血浆清除率表示）是对照组的12倍。对于这两种蛋白，淋巴通量都没有显著大于血管外摄取的值，这表明淋巴蛋白通量的持续增加不是由于间质蛋白的冲洗。在对照组和缓激肽动物中，IgG的血管外摄取大约是白蛋白的80%，这表明持续的反应并没有改变两种蛋白之间的选择性。内源性白蛋白和IgG血管外团块的变化表明，对缓激肽的最初反应是内皮间隙的短暂形成，对IgG跨血管运输的限制不如白蛋白大。
Bradykinin (1 microgram/min) was infused into the femoral artery of one hindleg of anesthetized rabbits for 3 h. Measurements of the initial extravascular uptake for labeled albumin and immunoglobulin (Ig) G were compared with measurements of the lymph protein flux for endogenous albumin and IgG. With bradykinin, the initial extravascular uptake for both albumin and IgG, calculated as the 1-h extravascular distribution space at plasma concentration divided by time and expressed as a plasma clearance, was 12 times the control values. For both proteins, the lymph fluxes were not significantly greater than the values for extravascular uptake, indicating that the sustained increase in lymph protein flux was not due to washout of interstitial protein. The extravascular uptake for IgG was approximately 80% of that for albumin in both control and bradykinin animals, suggesting that the sustained response did not change the selectivity between the two proteins. Changes in the extravascular masses of endogenous albumin and IgG suggest that the initial response to bradykinin was a transient formation of endothelial gaps that did not restrict transvascular IgG transport more than albumin.