Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression
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DOI：
10.1016/j.phymed.2010.08.011
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发表时间：
2011-03-15
期刊：
影响因子：
7.9
通讯作者：
Apryani, Evhy
中科院分区：
文献类型：
--
作者：
Idayu, N. Farah;Hidayat, M. Taufik;Apryani, Evhy
光叶水母。几十年来，树叶一直被马来西亚当地人用作治疗腹泻、糖尿病和改善血液循环的传统药物。泰国和东南亚其他地区。米拉吉宁是该植物中的主要活性生物碱。到目前为止，米拉吉宁在抑郁症等心理障碍中的作用还没有得到科学的评估。因此，本研究在小鼠强迫游泳实验(FST)和尾部悬吊实验(TST)这两个预测抗抑郁活性的模型上评价了米曲林的抗抑郁作用，并通过测定暴露于FST和TST的小鼠下丘脑-垂体-肾上腺(HPA)轴神经内分泌系统的皮质酮浓度来评价米曲宁对HPA轴神经内分泌的影响。开场测试(OFT)被用来检测FST和TST的不动与米曲林治疗的小鼠运动活动变化的任何关联。在本研究中，米拉吉宁10 mg/kg和30 mg/kg ip。注射后可明显缩短小鼠在FST和F1区的不动时间，但对OFT区小鼠的运动活动无明显影响。10 mg/kg和30 mg/kg剂量的FST和TST对小鼠皮质酮的释放有明显的抑制作用。总体而言，本研究清楚地表明，在抑郁的动物行为模型(FST和FIRST)中，米曲林具有抗抑郁作用，该作用似乎是通过与神经内分泌HPA轴系统的相互作用而实现的。(C)2010年爱思唯尔股份有限公司。版权所有。
Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia. Thailand and other regions of Southeast Asia. Mitragynine is the major active alkaloid in the plant. To date, the role of mitragynine in psychological disorders such as depression is not scientifically evaluated. Hence, the present investigation evaluates the antidepressant effect of mitragynine in the mouse forced swim test (FST) and tail suspension test (TST), two models predictive of antidepressant activity and the effect of mitragynine towards neuroendocrine system of hypothalamic-pituitary-adrenal (HPA) axis by measuring the corticosterone concentration of mice exposed to FST and 1ST. An open-field test (OFT) was used to detect any association of immobility in the FST and TST with changes in motor activity of mice treated with mitragynine. In the present study, mitragynine at dose of 10 mg/kg and 30 mg/kg i.p. injected significantly reduced the immobility time of mice in both FST and 1ST without any significant effect on locomotor activity in OFT. Moreover, mitragynine significantly reduced the released of corticosterone in mice exposed to FST and TST at dose of 10 mg/kg and 30 mg/kg. Overall, the present study clearly demonstrated that mitragynine exerts an antidepressant effect in animal behavioral model of depression (FST and 1ST) and the effect appears to be mediated by an interaction with neuroendocrine HPA axis systems. (C) 2010 Elsevier GmbH. All rights reserved.