SEQPWR and SEQOPR: computer programs for design of maximum information trials based on group sequential logrank tests.
SEQPWR and SEQOPR: computer programs for design of maximum information trials based on group sequential logrank tests.
复制标题
SEQPWR 和 SEQOPR：用于设计基于组序贯对数秩检验的最大信息试验的计算机程序。
DOI：
10.1016/0169-2607(94)01615-m
复制
发表时间：
1995
影响因子：
6.1
通讯作者：
Kim,K
中科院分区：
文献类型：
--
作者：
Kim,K
最大信息试验范式的失效时间数据的临床试验已被确认，并进行了研究。采用最大信息试验范式，如果没有因治疗差异或缺乏治疗差异而提前停止，则当已累积预定的最大关注事件数量（因此最大信息）时，研究结束。我们提出了两个交互式的FORTRAN程序，用于设计最大信息试验的基础上，成组序贯对数秩检验。程序SEQPWR计算给定累积和随访持续时间组合的组序贯对数秩检验的可达到功效。程序SEQOPR允许用户研究最大信息试验的操作特性，给出中期分析的信息分数。提供了来自东部肿瘤协作组的临床试验，以说明程序的使用和功能。
The maximum information trial paradigm for clinical trials with failure time data was recognized and has been investigated. With the maximum information trial paradigm, a study is concluded when a prespecified maximum number of events of interest, thus maximum information, has been accrued if there was no early stopping due to treatment difference or lack thereof. We present two interactive FORTRAN programs for use in designing maximum information trials based on group sequential logrank tests. The program SEQPWR computes the attainable power of group sequential logrank tests given the combinations of the accrual and follow-up durations. The program SEQOPR allows the users to investigate the operating characteristics of the maximum information trial given the information fractions of interim analyses. A clinical trial from the Eastern Cooperative Oncology Group is provided to illustrate the usage and features of the programs.