The age-associated alterations in late diastolic function in mice are improved by caloric restriction
The age-associated alterations in late diastolic function in mice are improved by caloric restriction
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DOI：
10.1093/gerona/52a.6.b285
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发表时间：
1997-11-01
影响因子：
5.1
通讯作者：
Hartley, CJ
中科院分区：
文献类型：
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作者：
Taffet, GE;Pham, TT;Hartley, CJ
限制热量摄入可以减少啮齿类动物许多与年龄相关的变化。在小鼠、大鼠和健康人中，心脏功能随着衰老而改变。我们采用多普勒技术，在自由采食的30- 32月龄（AL）和热量限制（CR）的32- 35月龄雌性B6 D2-F-1杂交小鼠体内原位检测了终身热量限制对心脏舒张和收缩功能的影响。AL（5.74 +/- .24 mg/g）和CR（5.68 +/- .20 mg/g）小鼠的心脏重量与体重比相似。两个收缩功能参数，已知降低与年龄ill人类和小鼠，峰值主动脉流速和主动脉加速度，CR相比AL不变。相反，舒张功能改变热量限制。尽管CR和AL的左心室早期堆积峰值速度（E）没有差异，但CR时心房充盈峰值速度（A）比AL低50%（p
Caloric restriction reduces the magnitude of many age-related changes tt rodents. Cardiac function is altered with senescence in mice, rats, and healthy humans. We examined the effects of life-long caloric restriction on diastolic and systolic cardiac function in situ using Doppler techniques irt ad libitum-fed 30- to 32-month-old (AL) and calorically restricted (CR) 32- to 35-month-old female B6D2-F-1 hybrid mice. The heart weight to body weight ratio was similar in AL (5.74 +/- .24 mg/g) and CR (5.68 +/- .20 mg/g) mice. Two systolic functional parameters known to decrease with age ill both humans and mice, peak aortic velocity and aortic acceleration, were unchanged by CR compared to AL. In contrast, diastolic function was altered by caloric restriction. Although left ventricular peak early piling velocity (E) was not different between CR and AL, peak atrial filling velocity (A) was 50% lower ill CR compared to AL (p