Quassinoids from Eurycoma longifolia
Quassinoids from Eurycoma longifolia
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DOI：
10.1021/np900486f
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发表时间：
2009-12-01
影响因子：
5.1
通讯作者：
Kadota, Shigetoshi
中科院分区：
文献类型：
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作者：
Miyake, Katsunori;Tezuka, Yasuhiro;Kadota, Shigetoshi
从东革阿里（Eurycoma longifolia）中分离得到10个新的苦木素类化合物（1-10）和14个已知化合物。新化合物为2个宽角木酮型C-20苦木素（1，2），1个klaineanone型C-20苦木素（3），1个C-19苦木素（4）具有1，2-seco-1-nor-6（5 -> 10）-abeo-picrasan-2，5-nitro骨架，和6个宽角木内酯型C-19苦木素（5-10）。化合物5和6均含有3，4-环氧基，这在广松内酯中是首次发现。化合物I在C-14处具有α-取向的OH基团，这在先前的宽木单酮型苦木素中没有报道。评价了所有分离物对高转移性HT-1080人纤维肉瘤细胞系的细胞毒性，化合物11、23和24显示出有效的细胞毒性（IC 50值0.93-1.1 μ M）。
Ten new structurally diverse quassinoids (1-10) and 14 known Compounds were isolated from the steins of Eurycoma longifolia. The new compounds were two eurycomanone-type C-20 quassinoids (1, 2), one klaineanone-type C-20 quassinoid (3), one C-19 quassinoid (4) with a 1,2-seco-1-nor-6(5 -> 10)-abeo-picrasan-2,5-olide skeleton, and six eurycomalactone-type C-19 quassinoids (5-10). Compounds 5 and 6 both possessed a 3,4-epoxy group observed for the first time in eurycomalactones. Compound I had an alpha-oriented OH group at C-14 that had not been reported previously in eurycomanone-type quassinoids. All of the isolates were evaluated for cytotoxicity toward the highly metastatic HT-1080 human fibrosarcoma cell line, and compounds 11, 23, and 24 showed potent cytotoxicity (IC50 values 0.93-1.1 mu M).