Significant Role of Tissue Engineering in Regenerative Medicine
Significant Role of Tissue Engineering in Regenerative Medicine
复制标题
组织工程在再生医学中的重要作用
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
D.Pharm.
中科院分区：
文献类型：
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作者：
Y. Tabata;D. Ph.;D.Pharm.
再生医学的目的是让细胞诱导身体组织的再生，从而导致检测组织的治疗性修复以及受损器官的生物功能的替代。随着基础医学和细胞生物学研究的发展，为细胞诱导再生创造合适的环境是成功实现组织再生的必要条件。组织工程是利用细胞、细胞支架、生长因子或三者的适当组合来构建这种环境的生物医学技术或方法。三维支架用于辅助细胞增殖和分化。生长因子是促进组织再生所必需的，同时它可以诱导血管生成，为移植细胞提供必要的氧气和营养，以确保移植细胞的存活和维持生物学功能。然而，由于生长因子在体内的稳定性差，以溶液形式使用的生长因子并不总是能够表现出生物学效应，除非应用药物递送系统（DDS）技术。本文除了简要介绍组织工程的概况外，还介绍了组织再生方面的一些研究数据，以强调组织工程在再生医学中的重要意义。
The objective of regenerative medicine is to allow cells to induce the regeneration of body tissues, resulting in therapeutic repair of detective tissues as well as substitution of the biological functions of damaged organs. With the development of research in basic medical science and biology on cells, it is indispensable to create a suitable environment for the cells to induce regeneration in order to achieve successful tissue regeneration. Tissue engineering is the biomedical technology or methodology to build this environment, utilizing cells, the cell scaffold, growth factors, or appropriate combinations of the three. A 3-dimensional scaffold is used to assist cell proliferation and differentiation. Growth factor is often required to promote tissue regeneration, while it can induce angiogenesis necessary for the supply of oxygen and nutrients to ensure survival of the transplanted cells and to maintain the biological functions. However, growth factor used in solution form cannot always be expected to manifest biological effects because of its poor in vivo stability, unless the technology of drug delivery systems (DDS) is applied. In this paper, in addition to a brief overview of tissue engineering, several research data on tissue regeneration are presented to emphasize the significance of tissue engineering in regenerative medicine.