Behavior change after growth hormone treatment of children with short stature.
Behavior change after growth hormone treatment of children with short stature.
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DOI：
10.1016/s0022-3476(98)70271-9
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发表时间：
1998-09
期刊：
影响因子：
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通讯作者：
B. Stabler;P. Siegel;R. Clopper;C. Stoppani;P. Compton;L. Underwood
中科院分区：
文献类型：
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作者：
B. Stabler;P. Siegel;R. Clopper;C. Stoppani;P. Compton;L. Underwood
目的 测量身材矮小儿童行为和学习问题的患病率，并评估生长激素 (GH) 治疗对此类问题的效果。研究设计 总共 195 名身材矮小儿童（年龄范围 5 至 16 岁，平均年龄 11.2 岁）在开始 GH 治疗前以及治疗期间每年进行智力、学业成绩、社交能力和行为问题测试。当 GH 对刺激刺激的反应<10 ng/mL (n = 109) 时，儿童被归类为生长激素缺乏症 (GHD)；当 GH > 10 ng/mL (n = 86) 时，儿童被归类为特发性身材矮小 (ISS)。正常身材的匹配对照组仅在基线时进行测试。结果GHD 组中的 72 名儿童和 ISS 组中的 59 名儿童完成了 3 年的 GH 治疗和心理测量测试。身材矮小的儿童的平均智商接近平均水平。生长激素治疗后智商和成绩得分没有变化。身材矮小儿童的儿童行为检查表总行为问题得分高于正常身材儿童 (P < .001)。经过 3 年 GH 治疗后，GHD (P < .001) 和 ISS (P < .003) 患者的这些评分有所改善。此外，GHD 组儿童的内化分量表（撤回：P < .007；躯体并发症，P < .001；焦虑/抑郁，P < .001）和未分组分量表的 3 个组成部分（注意力、社会问题和思维问题，每个 P = .001）的分数均有所改善。在 GHD 组中观察到的效果比 ISS 组更大。 结论 许多身材矮小的儿童都存在行为问题，其中一些问题在 GH 治疗期间得到改善。 （儿科杂志 1998；133：366-73）
ObjectivesTo measure the prevalence of behavioral and learning problems among children with short stature and to assess the effect of growth hormone (GH) treatment on such problems.Study designA total of 195 children with short stature (age range 5 to 16 years, mean age 11.2 years) were tested for intelligence, academic achievement, social competence, and behavior problems before beginning GH therapy and yearly during 3 years of treatment. Children were classified as having growth hormone deficiency (GHD) when GH responses to provocative stimuli were <10 ng/mL (n = 109) and as having idiopathic short stature (ISS) when >10 ng/mL (n = 86). A normal-statured matched comparison group was tested at the baseline only.ResultsSeventy-two children in the GHD group and 59 children in the ISS group completed 3 years of GH therapy and psychometric testing. Mean IQs of the children with short stature were near average. IQs and achievement scores did not change with GH therapy. Child Behavior Checklist scores for total behavior problems were higher (P < .001) in the children with short stature than in the normal-statured children. After 3 years of GH therapy these scores were improved in patients with GHD (P < .001) and ISS (P < .003). Also, there was improvement in the scores of children in the GHD group in the internalizing subscales (withdrawn: P < .007; somatic complications, P < .001; anxious/depressed, P < .001) and on the 3 components of the ungrouped subscales (attention, social problems, and thought problems, each P = .001). Larger effects were observed in the GHD group than in the ISS group.ConclusionsMany referred children with short stature have problems in behavior, some of which ameliorate during treatment with GH. (J Pediatr 1998;133:366-73)