Maternal Urinary Bisphenol A during Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study
Maternal Urinary Bisphenol A during Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study
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DOI：
10.1289/ehp.1205092
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发表时间：
2013-01-01
影响因子：
10.4
通讯作者：
Harley, Kim G.
中科院分区：
文献类型：
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作者：
Chevrier, Jonathan;Gunier, Robert B.;Harley, Kim G.
背景技术背景：双酚A（BPA）广泛用于制造聚碳酸酯塑料瓶、食品和饮料罐内衬、热收据和牙科密封剂。动物和人类研究表明，BPA可能会破坏甲状腺功能。虽然甲状腺激素在人类生长和大脑发育中起决定性作用，但目前还没有研究探讨BPA暴露与孕妇或新生儿甲状腺功能之间的关系。目的：我们的目标是评估妊娠期间暴露于BPA是否与孕妇和新生儿的甲状腺激素水平有关。我们测量了476名参与CHAMACOS（萨利纳斯母亲和儿童健康评估中心）研究的妇女在怀孕前半期和后半期收集的尿液样本中的BPA浓度。我们还测量了游离甲状腺素（T-4），总T-4，和促甲状腺激素（TSH）的妇女在怀孕期间，和新生儿TSH。在两次BPA测量中，只有在时间上最接近TH测量的一次测量与总T-4的减少显著相关（β = -0.13 μ g/dL/log（2）单位; 95% CI：-0.25，0.00）。母体BPA浓度的平均值与男孩的TSH降低相关（-9.9%/log（2）单位; 95% CI：-15.9%，-3.5%），但与女孩无关。在男孩中，当BPA测量在怀孕的第三个三个月和BPA和TH measurement.CONCLUSION：结果表明，在怀孕期间暴露于BPA是与减少总T-4在孕妇和男性新生儿TSH下降。研究结果可能对胎儿和新生儿的发育有影响。
BACKGROUND: Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain development, no studies have investigated relations between BPA exposure and thyroid function in pregnant women or neonates.OBJECTIVE: Our goal was to evaluate whether exposure to BPA during pregnancy is related to thyroid hormone levels in pregnant women and neonates.METHODS: We measured BPA concentration in urine samples collected during the first and second half of pregnancy in 476 women participating in the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) study. We also measured free thyroxine (T-4), total T-4, and thyroid-stimulating hormone (TSH) in women during pregnancy, and TSH in neonates.RESULTS: Associations between the average of the two BPA measurements and maternal thyroid hormone levels were not statistically significant. Of the two BPA measurements, only the one taken closest in time to the TH measurement was significantly associated with a reduction in total T-4 (beta = -0.13 mu g/dL per log(2) unit; 95% CI: -0.25, 0.00). The average of the maternal BPA concentrations was associated with reduced TSH in boys (-9.9% per log(2) unit; 95% CI: -15.9%, -3.5%) but not in girls. Among boys, the relation was stronger when BPA was measured in the third trimester of pregnancy and decreased with time between BPA and TH measurements.CONCLUSION: Results suggest that exposure to BPA during pregnancy is related to reduced total T-4 in pregnant women and decreased TSH in male neonates. Findings may have implications for fetal and neonatal development.