Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
复制标题
未接受药物治疗的精神分裂症患者在接受 6 周抗精神病药物治疗后，壳核体积增加与阳性症状减少相关
DOI：
10.1017/s0033291711002157
复制
发表时间：
2012-07-01
影响因子：
6.9
通讯作者：
Li, T.
中科院分区：
文献类型：
--
作者：
Li, M.;Chen, Z.;Li, T.
背景。抗精神病药物使用后大脑结构似乎会发生改变，但尚不清楚这些改变是否与精神分裂症患者精神病理学的改善有关。在本研究中，作者探讨了这种关系。
方法。共有66名首发、未用药的精神分裂症患者和23名匹配良好的健康对照者在基线时接受了脑部磁共振成像扫描。在6周随访后，对所有23名健康对照者和42名患者再次进行扫描。患者在6周期间接受常规抗精神病治疗，并在基线和6周时使用阳性和阴性症状量表（PANSS）评估其精神病理学。基线和6周时PANSS评分的差异以基线评分的比率表示——“PANSS减少比率”。应用一种改进的基于张量的形态测量方法分析纵向图像。探究了区域体积变化、PANSS减少比率和抗精神病药物剂量之间的相关性。
结果。与健康对照者相比，患者在治疗6周后右侧壳核的灰质体积显著增加。这种体积变化与PANSS阳性症状减少得分呈正相关，但与药物剂量无关。
结论。首发精神分裂症患者在抗精神病治疗6周后壳核体积增加。增加的体积与精神病理学的改善密切相关，表明壳核可能是预测精神分裂症治疗反应的一个生物标志物。
Background Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship. Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline – ‘PANSS reduction ratio’. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored. Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages. Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia.