Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum.
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum.
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DOI：
10.3390/pharmaceutics7040438
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发表时间：
2015-10-22
期刊：
影响因子：
5.4
通讯作者：
Donnelly RF
中科院分区：
文献类型：
--
作者：
Alkilani AZ;McCrudden MT;Donnelly RF
皮肤为给药提供了一个可接近和方便的部位。为此，旨在开发安全有效的药物经皮肤递送的手段的经皮药物递送领域，随着新的和创新的方法的不断发展，过去已经并将继续获得大量的时间和投资。这篇综述详细介绍了经皮给药领域的进展和现状，并描述了许多药物的发展，已被用来克服与皮肤给药系统的限制。详细介绍了各种方法的优点和缺点，强调了商业化销售的产品，并特别注意新兴的微针技术领域。
The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.