Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats.
Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats.
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跑步机运动通过增强注意力缺陷/多动障碍大鼠的脑源性神经营养因子的表达来提高空间学习能力。
DOI：
10.12965/jer.140111
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发表时间：
2014-06
影响因子：
1.9
通讯作者：
Choi SW
中科院分区：
文献类型：
--
作者：
Jeong HI;Ji ES;Kim SH;Kim TW;Baek SB;Choi SW
注意力缺陷多动障碍（ADHD）患者表现出学习困难和冲动。众所周知，锻炼可以提高学习能力和记忆功能。在本研究中，我们研究了跑台运动对ADHD大鼠空间学习能力的影响与脑源性神经营养因子（BDNF）表达的持续时间依赖性。本研究采用放射状八臂迷宫实验和蛋白质印迹法检测BDNF和酪氨酸激酶B（Trk B）的表达。以自发性高血压大鼠作为ADHD大鼠，以Wistar-Kyoto大鼠作为对照大鼠。运动组大鼠在跑台上连续跑10 min、30 min和60 min，每天1次，连续28 d。注意缺陷多动障碍大鼠的空间学习能力受损，而跑台运动可改善其空间学习能力受损。每天30 min跑台运动对空间学习能力的改善作用最强。ADHD大鼠海马BDNF和TrkB的表达减少，而跑台运动则增加了BDNF和TrkB的表达。每天跑台运动30 min和60 min可增强BDNF和TrkB的表达。跑台运动可通过增强BDNF和TrkB的表达来改善ADHD大鼠的空间学习能力。每天30分钟的跑步机运动可以被认为是ADHD症状的最有效的治疗方式。
Attention-deficit/hyperactivity disorder (ADHD) patients show learning difficulty and impulsiveness. Exercise is known to improve learning ability and memory function. In the present study, we investigated the duration-dependence of the effect of treadmill exercise on spatial learning ability in relation with brain-derived neurotrophic factor (BDNF) expression in ADHD rats. For this study, radial 8-arm maze test and western blot for BDNF and tyrosine kinase B (TrkB) were performed. Spontaneous hypertensive rats were used as the ADHD rats and Wistar-Kyoto rats were used as the control rats. The rats in the exercise groups were forced to run on a treadmill for 10 min, 30 min, and 60 min once a day for 28 consecutive days. ADHD rats displayed impairment of spatial learning ability, in contrast treadmill exercise ameliorated impairment of spatial learning ability. Treadmill exercise for 30 min per day showed most potent ameliorating effect on impairment of spatial learning ability. BDNF and TrkB expressions in the hippocampus were decreased in the ADHD rats, in contrast treadmill exercise enhanced BDNF and TrkB expressions. Treadmill exercise for 30 min and for 60 min per day showed enhancing effects on BDNF and TrkB expressions. Treadmill exercise alleviated deficits in the spatial learning ability through enhancing BDNF and TrkB expressions in the ADHD rats. Treadmill exercise for 30 min per day can be considered as the most effective therapeutic modality for the ADHD symptoms.
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DOI：
10.1016/j.apmr.2009.01.026
发表时间：
2009-07-01
影响因子：
4.3
作者：
Shurtleff, Tim L.;Standeven, John W.;Engsberg, Jack R.
通讯作者：
Engsberg, Jack R.
影响因子：
3.2
作者：
Fetters, L;Kluzik, J
通讯作者：
Kluzik, J
影响因子：
2.2
作者：
Lechner, HE;Feldhaus, S;Knecht, H
通讯作者：
Knecht, H
影响因子：
2.3
作者：
Herrero, Pablo;Asensio, Angel;Casas, Roberto
通讯作者：
Casas, Roberto
DOI：
10.1111/j.1469-8749.2008.03196.x
发表时间：
2009-04-01
影响因子：
3.8
作者：
Hanna, Steven E.;Rosenbaum, Peter L.;Russell, Dianne J.
通讯作者：
Russell, Dianne J.