No Evidence of Association between HIV-1 and Malaria in Populations with Low HIV-1 Prevalence
No Evidence of Association between HIV-1 and Malaria in Populations with Low HIV-1 Prevalence
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DOI：
10.1371/journal.pone.0023458
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发表时间：
2011-08-12
期刊：
影响因子：
3.7
通讯作者：
Garcia-Ramos, Gisela
中科院分区：
文献类型：
--
作者：
Cuadros, Diego F.;Branscum, Adam J.;Garcia-Ramos, Gisela
背景：HIV-1和疟疾之间的地理重叠引起了人们对它们之间潜在相互作用的极大兴趣。各种研究证明，艾滋病毒和疟疾在个人和人群中存在复杂的相互作用，可能产生巨大影响，但在人群一级合并感染的原因和影响仍不清楚。在以前的出版物中，我们表明，由寄生虫恶性疟原虫引起的疟疾的流行与撒哈拉以南非洲东部的艾滋病毒感染有关。为了补充我们的知识，艾滋病毒-疟疾合并感染，这项工作的目的是评估疟疾和艾滋病毒的流行率之间的关系在撒哈拉以南非洲西部地区。方法/主要调查结果：人口为基础的横截面数据从艾滋病毒/艾滋病人口和健康调查在布基纳法索，加纳，几内亚，马里，利比里亚和喀麦隆进行，疟疾地图集项目。使用广义线性混合模型，我们评估了HIV-1和恶性疟原虫寄生虫率（PfPR）之间的关系，调整重要的社会经济和生物辅助因素。我们没有发现任何证据表明生活在疟疾传播稳定地区（PfPR> 0.46）的个人比生活在PfPR地区的个人有更高的HIV阳性几率
Background: The geographic overlap between HIV-1 and malaria has generated much interest in their potential interactions. A variety of studies have evidenced a complex HIV-malaria interaction within individuals and populations that may have dramatic effects, but the causes and implications of this co-infection at the population level are still unclear. In a previous publication, we showed that the prevalence of malaria caused by the parasite Plasmodium falciparum is associated with HIV infection in eastern sub-Saharan Africa. To complement our knowledge of the HIV-malaria co-infection, the objective of this work was to assess the relationship between malaria and HIV prevalence in the western region of sub-Saharan Africa.Methodology/Principal Findings: Population-based cross-sectional data were obtained from the HIV/AIDS Demographic and Health Surveys conducted in Burkina Faso, Ghana, Guinea, Mali, Liberia and Cameroon, and the malaria atlas project. Using generalized linear mixed models, we assessed the relationship between HIV-1 and Plasmodium falciparum parasite rate (PfPR) adjusting for important socio-economic and biological cofactors. We found no evidence that individuals living in areas with stable malaria transmission (PfPR>0.46) have higher odds of being HIV-positive than individuals who live in areas with PfPR