Effects of Prednisolone on Refractory Mycoplasma Pneumoniae Pneumonia in Children
Effects of Prednisolone on Refractory Mycoplasma Pneumoniae Pneumonia in Children
复制标题
DOI：
10.1002/ppul.22752
复制
发表时间：
2014-04-01
影响因子：
3.1
通讯作者：
Fu, Zhou
中科院分区：
文献类型：
--
作者：
Luo, Zhengxiu;Luo, Jian;Fu, Zhou
目的前瞻性评价泼尼松龙治疗难治性肺炎支原体肺炎（MPP）的疗效。方法58例难治性MPP患儿随机分为阿奇霉素联合泼尼松龙治疗组（治疗组）28例和阿奇霉素单药治疗组（对照组）30例。在入组研究时及入组后每8小时检查一次体温、呼吸道症状和体征，并于入组后第7天评估浸润吸收、肺不张消退、胸腔积液消失、血清铁蛋白和LDH水平。低氧血症平均持续时间治疗组为1.9 ± 0.9天，对照组为2.7 ± 1.1天（P
ObjectivesTo prospectively evaluate prednisolone treatment in children with refractory Mycoplasma pneumonia pneumonia (MPP).MethodsFifty-eight refractory children with MPP were enrolled to receive either azithromycin combined with prednisolone (treatment group, n=28) or azithromycin alone (control group, n=30). Temperature, respiratory symptoms and signs were examined at the time of study entry and every 8hr after enrollment, infiltration absorption, atelectasis resolution, pleural effusion disappearance, and serum ferritin and LDH levels were assessed on seventh day after enrollment.ResultsAll patients in treatment group achieved defervescence during 8-48hr after enrollment versus no patient in the control group. The mean duration of hypoxemia was 1.90.9 days in treatment group and 2.7 +/- 1.1 days in the control group (P