Arrhythmia in hypertrophic cardiomyopathy. I: Influence on prognosis.
Arrhythmia in hypertrophic cardiomyopathy. I: Influence on prognosis.
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肥厚型心肌病的心律失常。
DOI：
10.1136/hrt.46.2.168
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发表时间：
1981
影响因子：
--
通讯作者：
J. Goodwin
中科院分区：
文献类型：
--
作者：
W. Mckenna;D. England;Y. Doi;J. Deanfield;C. Oakley;J. Goodwin
为了研究心律失常与预后之间的关系，我们对86例肥厚性心肌病患者进行了72小时动态心电图监测。在监测期间，23例患者至少发生一次室上性心动过速，24例发生室性心动过速（其中10例超过三次）。然后对患者进行平均2.6年的随访（范围1至4年）。7名患者突然死亡。其中5例表现为多种形式的室性早搏和室性心动过速。这些心律失常与猝死显著相关，而室上性心律失常与猝死无关。突然死亡的患者年龄较大，症状较多，其中3例有肥厚性心肌病和猝死家族史。这一经验为肥厚性心肌病合并严重室性心律失常患者的治疗评估提供了依据。
In order to examine the association between arrhythmia and subsequent prognosis, 72-hour ambulatory electrocardiographic monitoring was performed in 86 unselected patients with hypertrophic cardiomyopathy. During monitoring 23 patients experienced at least one episode of supraventricular tachycardia and 24 had ventricular tachycardia (of whom 10 had more than three episodes). The patients were then followed for a mean of 2.6 years (range one to four). Seven patients died suddenly. Of these, five had exhibited multiform and paired ventricular extrasystoles and ventricular tachycardia. These arrhythmias were significantly associated with sudden death whereas supraventricular arrhythmias were not. The patients who died suddenly were older and had experienced more symptoms than the survivors, and three had a family history of hypertrophic cardiomyopathy and sudden death. This experience provides the basis for the assessment of treatment in patients with hypertrophic cardiomyopathy and serious ventricular arrhythmia.