Mycapolyols A-F, new cytotoxic metabolites of mixed biogenesis from the marine sponge Mycale izuensis

Mycapolyols A-F, new cytotoxic metabolites of mixed biogenesis from the marine sponge Mycale izuensis
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DOI:
10.1021/ol050648m
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发表时间:
2005-05-26
期刊:
影响因子:
5.2
通讯作者:
Fusetani, N
Fusetani, N
中科院分区:
化学1区
文献类型:
--
作者:
Phuwapraisirisan, P;Matsunaga, S;Fusetani, N

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从伊苏海绵Mycale izuensis中分离得到6个新的PKS/NRPS代谢产物Mycapolyols A-F(1-6)。通过波谱数据分析确定了其结构,并利用化学方法和通用NMR数据库建立了其立体化学。
Mycapolyols A-F (1-6), six new unusual PKS/NRPS metabolites, were isolated from the marine sponge Mycale izuensis. The gross structures were elucidated by analysis of spectroscopic data, while the stereochemistry was established using chemical method and the universal NMR database.