Design and production of 3D printed bolus for electron radiation therapy.
Design and production of 3D printed bolus for electron radiation therapy.
复制标题
DOI：
10.1120/jacmp.v15i4.4831
复制
发表时间：
2014-07-08
影响因子：
2.1
通讯作者：
Robar JL
中科院分区：
文献类型：
--
作者：
Su S;Moran K;Robar JL
这是一项概念验证研究，证明了使用3D打印团注进行调制电子放射治疗（MERT）剂量分布的能力。以前的报告涉及使用电子笔形束模型和使用铣床制造的弹丸设计。在本研究中，提出了一种内部算法，可优化计划靶体积（PTV）内剂量覆盖、符合性和均匀性方面的剂量分布。该算法利用商业电子蒙特卡罗剂量计算，并使用计算结果作为输入。沿射线从90%等剂量线的远端侧到PTV的远端表面的距离沿着用于估计团厚度。计算体积内的不均匀性采用等效厚度系数法计算。采用区域调制算子提高了剂量覆盖率和剂量均匀性。重复该过程（通常两次），直到实现可接受的MERT计划，并使用固体聚乳酸打印最终推注。该方法进行了评估，定期几何幻影，拟人幻影，和临床横纹肌肉瘤儿科病例。在所有情况下，与均匀推注相比，剂量一致性得到改善。对于具有空气或骨不均匀性的几何体模，剂量均匀性显著改善。实际打印的药丸与复杂的拟人幻影的表面非常吻合。显示了计算的合成大剂量和实际制造的大剂量之间的剂量分布的对应关系。对于横纹肌肉瘤患者，MERT计划使左肾平均剂量相对于均匀推注减少38.2%。使用3D打印推注的MERT似乎是一种实用、低成本的方法，可以生成用于电子治疗的优化推注。该方法有效地改善了处方等剂量面的一致性，并保留了紧邻的正常组织。PACS编号：81.40.Wx
This is a proof‐of‐concept study demonstrating the capacity for modulated electron radiation therapy (MERT) dose distributions using 3D printed bolus. Previous reports have involved bolus design using an electron pencil beam model and fabrication using a milling machine. In this study, an in‐house algorithm is presented that optimizes the dose distribution with regard to dose coverage, conformity, and homogeneity within the planning target volume (PTV). The algorithm takes advantage of a commercial electron Monte Carlo dose calculation and uses the calculated result as input. Distances along ray lines from the distal side of 90% isodose line to distal surface of the PTV are used to estimate the bolus thickness. Inhomogeneities within the calculation volume are accounted for using the coefficient of equivalent thickness method. Several regional modulation operators are applied to improve the dose coverage and uniformity. The process is iterated (usually twice) until an acceptable MERT plan is realized, and the final bolus is printed using solid polylactic acid. The method is evaluated with regular geometric phantoms, anthropomorphic phantoms, and a clinical rhabdomyosarcoma pediatric case. In all cases the dose conformity are improved compared to that with uniform bolus. For geometric phantoms with air or bone inhomogeneities, the dose homogeneity is markedly improved. The actual printed boluses conform well to the surface of complex anthropomorphic phantoms. The correspondence of the dose distribution between the calculated synthetic bolus and the actual manufactured bolus is shown. For the rhabdomyosarcoma patient, the MERT plan yields a reduction of mean dose by 38.2% in left kidney relative to uniform bolus. MERT using 3D printed bolus appears to be a practical, low‐cost approach to generating optimized bolus for electron therapy. The method is effective in improving conformity of the prescription isodose surface and in sparing immediately adjacent normal tissues. PACS number: 81.40.Wx
登录
查看更多内容
影响因子：
3.8
作者：
Karlsson, MG;Karlsson, M;Ma, CM
通讯作者：
Ma, CM
影响因子：
3.5
作者：
Gauer, T.;Sokoll, J.;Schmidt, R.
通讯作者：
Schmidt, R.
影响因子：
5.7
作者：
Klein, EE
通讯作者：
Klein, EE
影响因子：
1.2
作者：
Kim, Michelle M.;Kudchadker, Rajat J.;Perkins, George H.
通讯作者：
Perkins, George H.
影响因子：
2.1
作者：
Kudchadker, R J;Antolak, J A;Hogstrom, K R
通讯作者：
Hogstrom, K R