The Chemistry of Lanthanide MRI Contrast Agents
The Chemistry of Lanthanide MRI Contrast Agents
复制标题
稀土 MRI 造影剂的化学性质
DOI：
10.1002/9781118854754.ch8
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发表时间：
2014
期刊：
影响因子：
3
通讯作者：
O. Blackburn
中科院分区：
文献类型：
--
作者：
S. Faulkner;O. Blackburn
含钆造影剂广泛用于辅助磁共振成像（MRI）图像的采集和判读。非内源性顺磁性物质通过改变本体水质子的局部弛豫速率来提供增强的图像对比度和更短的图像采集时间。自旋-晶格弛豫时间（T1）和自旋-自旋弛豫时间（T2）都可以以这种方式受到影响。本章考虑了镧系元素配合物作为T1造影剂的作用，当应用合适的成像脉冲序列并进行去卷积时，镧系元素配合物会产生T1加权图像。弛豫率是复合物作为造影剂的有效性的有用量度;最好的造影剂将具有每mmol钆的大弛豫率，有效地意味着可以用较低浓度的造影剂获得良好的图像。本章还讨论了增加弛豫率的策略。
Contrast agents containing gadolinium are widely used to assist in the acquisition and interpretation of magnetic resonance imaging (MRI) images. Non‐endogenous paramagnetic species provide enhanced image contrast and shorter image acquisition times through changing the local relaxation rates of bulk water protons. Both spin‐lattice relaxation time (T1) and spin‐spin relaxation time (T2) can be influenced in this way. This chapter considers the role of lanthanide complexes as T1contrast agents, which produce T1weighted images when suitable imaging pulse sequences are applied and deconvoluted. Relaxivity is a useful measure of the effectiveness of a complex as a contrast agent; the best contrast agents will have large relaxivities per mmol of gadolinium, effectively meaning that good images can be obtained with lower concentrations of contrast agent. The chapter also discusses the strategies for increasing relaxivity.
影响因子：
4.6
作者：
Caravan, P;Greenfield, MT;Sherry, AD
通讯作者：
Sherry, AD
影响因子：
18.3
作者：
Major, Jody L.;Meade, Thomas J.
通讯作者：
Meade, Thomas J.
影响因子：
2.9
作者：
Visser,AJ;Ykema,T;vanHoek,A;O'Kane,DJ;Lee,J
通讯作者：
Lee,J