Signaling Pathways Controlling Microglia Chemotaxis.
Signaling Pathways Controlling Microglia Chemotaxis.
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DOI：
10.14348/molcells.2017.0011
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发表时间：
2017-03
影响因子：
3.8
通讯作者：
Chung CY
中科院分区：
文献类型：
--
作者：
Fan Y;Xie L;Chung CY
小胶质细胞是中枢神经系统（CNS）的主要常驻免疫细胞。它们是大脑对感染、损伤和疾病的先天免疫反应的第一道防线。小胶质细胞对细胞外信号作出反应，并通过吞噬作用吞噬不需要的神经元碎片，从而维持CNS中的正常细胞稳态。病理刺激，如神经元损伤诱导转化和激活的休息小胶质细胞与分枝形态到一个能动的变形虫的形式和激活的小胶质细胞趋化病变部位。本文就小胶质细胞的活化和趋化性的研究进展作一综述。
Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain’s innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.