Transient Receptor Potential (TRP) channels in T cells.
Transient Receptor Potential (TRP) channels in T cells.
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DOI：
10.1007/s00281-015-0535-z
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发表时间：
2016-05
影响因子：
9
通讯作者：
Raz E
中科院分区：
文献类型：
--
作者：
Bertin S;Raz E
瞬时受体电位（Transient Receptor Potential， TRP）离子通道家族在多种细胞类型中广泛表达，并发挥多种生理作用。越来越多的证据表明，某些TRP通道在免疫系统中有功能性表达。事实上，越来越多的报道已经证明了一些TRP通道在先天和适应性免疫细胞中的功能性表达，并强调了它们在这些细胞的激活和功能中的关键作用。然而，很少有评论完全致力于这个主题。在这里，我们将总结关于TRP通道在T细胞中的表达的最新发现，并讨论它们作为T细胞激活和功能调节剂的新作用。此外，这些研究表明，除了它们在疼痛管理方面的药物利益之外，某些TRP通道可能代表各种免疫相关疾病的潜在新治疗靶点。
The Transient Receptor Potential (TRP) family of ion channels is widely expressed in many cell types and plays various physiological roles. Growing evidence suggests that certain TRP channels are functionally expressed in the immune system. Indeed, an increasing number of reports have demonstrated the functional expression of several TRP channels in innate and adaptive immune cells and have highlighted their critical role in the activation and function of these cells. However, very few reviews have been entirely dedicated to this subject. Here, we will summarize the recent findings with regards to TRP channel expression in T cells and discuss their emerging role as regulators of T cell activation and functions. Moreover, these studies suggest that beyond their pharmaceutical interest in pain management, certain TRP channels may represent potential novel therapeutic targets for various immune-related diseases.