Flow analyses in the lower airways:: Patient-specific model and boundary conditions
Flow analyses in the lower airways:: Patient-specific model and boundary conditions
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DOI：
10.1016/j.medengphy.2007.11.002
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发表时间：
2008-09-01
影响因子：
2.2
通讯作者：
De Backer, W.
中科院分区：
文献类型：
--
作者：
De Backer, J. W.;Vos, W. G.;De Backer, W.
计算流体动力学（CFD）越来越多地应用于呼吸领域。模拟通过分叉管状系统的流动的能力增加了对内部流动动力学和呼吸流的特定特性（例如二次运动和惯性效应）的了解。下一步的发展是将该技术应用于患者特定的情况下，以提供更多的信息病理airways.This研究提出了一种患者特定的方法，其中的几何形状和边界条件（BC）是基于个人的成像方法，使用计算机断层扫描（CT）。评估了一位73岁女性慢性阻塞性肺疾病（COPD）患者的内部流量分布。验证是通过比较肺通气与伽玛射线血管造影进行的，结果表明，为了在伽玛射线血管造影扫描的准确性范围内获得一致性，患者特定的几何形状和BC（驱动压力）起着至关重要的作用。微创测试（CT扫描）提供了足够的信息进行准确的CFD分析。最后，利用成像和计算流体动力学技术可以捕获呼吸系统的病理特征。这使这项新技术在临床实践中的引入更近了一步。(C)2007年妇女平等问题国际研究所。由爱思唯尔有限公司出版。保留所有权利。
Computational fluid dynamics (CFD) is increasingly applied in the respiratory domain. The ability to simulate the flow through a bifurcating tubular system has increased the insight into the internal flow dynamics and the particular characteristics of respiratory flows such as secondary motions and inertial effects. The next step in the evolution is to apply the technique to patient-specific cases, in order to provide more information about pathological airways.This study presents a patient-specific approach where both the geometry and the boundary conditions (BC) are based on individual imaging methods using computed tomography (CT). The internal flow distribution of a 73-year-old female suffering from chronic obstructive pulmonary disease (COPD) is assessed. The validation is performed through the comparison of lung ventilation with gamma scintigraphy.The results show that in order to obtain agreement within the accuracy limits of the gamma scintigraphy scan, both the patient-specific geometry and the BC (driving pressure) play a crucial role. A minimal invasive test (CT scan) supplied enough information to perform an accurate CFD analysis. In the end it was possible to capture the pathological features of the respiratory system using the imaging and computational fluid dynamics techniques. This brings the introduction of this new technique in the clinical practice one step closer. (C) 2007 IPEM. Published by Elsevier Ltd. All rights reserved.