An artificial amino acid radiopharmaceutical for single photon emission computed tomographic study of pancreatic amino acid transports123I-3-iodo-alpha-methyl-L-tyrosine
An artificial amino acid radiopharmaceutical for single photon emission computed tomographic study of pancreatic amino acid transports123I-3-iodo-alpha-methyl-L-tyrosine
复制标题
用于单光子发射计算机断层扫描研究胰腺氨基酸转运的人造氨基酸放射性药物123I-3-碘-α-甲基-L-酪氨酸
DOI：
10.1007/bf03178309
复制
发表时间：
1992
影响因子：
2.6
通讯作者：
A. Yokoyama
中科院分区：
文献类型：
--
作者：
K. Kawai;Y. Fujibayashi;Y. Yonekura;J. Konishi;H. Saji;A. Kubodera;A. Yokoyama
Abstract123I-3-iodo-alpha-methyl-L-tyrosine (123I-L-AMT) was selected and its characteristics on pancreas accumulation, metabolic selectivity and metabolic stability of125I-L-AMT were studied. The studies on rat tissue slice as well as mouse biodistribution proved very high accumulation of125I-labeled L-AMT in the pancreas, which was remarkably inhibited by the active transport inhibitor, ouabain.125I-L-AMT does not enter into protein synthesis and general amino acid catabolism. Moreover,125I-L-AMT was very stable against enzymatic deiodination. Thus, the above studies indicated that the123I-labeled L-AMT was an “artificial amino acid” radiopharmaceutical to be used for the selective measurement of the membrane amino acid transport rate in the pancreas.
