New gene targets of PGC-1α and ERRa co-regulation in C2C12 myotubes
New gene targets of PGC-1α and ERRa co-regulation in C2C12 myotubes
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DOI：
10.1007/s11033-014-3698-0
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发表时间：
2014-12-01
影响因子：
2.8
通讯作者：
Foletta, Victoria C.
中科院分区：
文献类型：
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作者：
Nsiah-Sefaa, Abena;Brown, Erin L.;Foletta, Victoria C.
作为一种转录辅激活因子，PGC-1 α参与骨骼肌健康和疾病中广泛的代谢过程的调节；然而，关于它转录调节的基因的信息有限。为了寻找新的PGC-la调控的潜在基因靶点，通过芯片分析筛选PGC-1 α过表达后的小鼠C2C12肌管。mRNA表达量在2.5倍以上的基因(P
As a transcriptional coactivator, PGC-1 alpha contributes to the regulation of a broad range of metabolic processes in skeletal muscle health and disease; however, there is limited information about the genes it transcriptionally regulates. To identify new potential gene targets of PGC-la regulation, mouse C2C12 myotubes were screened by microarray analysis following PGC-1 alpha overexpression. Genes with an mRNA expression of 2.5-fold or more (P