Macrophages and Iron Metabolism.
Macrophages and Iron Metabolism.
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DOI：
10.1016/j.immuni.2016.02.016
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发表时间：
2016-03-15
期刊：
影响因子：
32.4
通讯作者：
Hamza I
中科院分区：
文献类型：
--
作者：
Soares MP;Hamza I
铁是一种过渡金属，由于其与各种分子交换电子的固有能力，对维持生命至关重要。在哺乳动物中，铁主要以血红素的形式存在，封闭在有机原卟啉环中，主要作为蛋白质中的辅基。特别地，当与氧的电子交换不受限制并催化活性氧物质的产生时，游离铁也具有成为细胞毒性的潜力。这些生物学特性要求铁代谢受到严格调节，以便铁可用于核心生物学功能，同时防止其细胞毒性作用。宏观经济在建立这种微妙的平衡方面发挥着核心作用。在这里，我们回顾了巨噬细胞对血红素铁代谢的影响，以及血红素铁如何调节巨噬细胞的功能。
Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of molecules is essential to support life. In mammals, iron exists mostly in the form of heme, enclosed within an organic protoporphyrin ring and functioning primarily as a prosthetic group in proteins. Paradoxically, free iron also has the potential to become cytotoxic when electron exchange with oxygen is unrestricted and catalyzes the production of reactive oxygen species. These biological properties demand that iron metabolism is tightly regulated such that iron is available for core biological functions whilst preventing its cytotoxic effects. Macrophages play a central role in establishing this delicate balance. Here, we review the impact of macrophages on heme-iron metabolism and, reciprocally, how heme-iron modulates macrophage function.