Influence of Nucleated Cell Dose on Overall Survival of Unrelated Cord Blood Transplantation for Patients with Severe Acquired Aplastic Anemia: A Study by Eurocord and the Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
Influence of Nucleated Cell Dose on Overall Survival of Unrelated Cord Blood Transplantation for Patients with Severe Acquired Aplastic Anemia: A Study by Eurocord and the Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
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DOI：
10.1016/j.bbmt.2010.06.011
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发表时间：
2011-01-01
影响因子：
4.3
通讯作者：
Rocha, Vanderson
中科院分区：
文献类型：
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作者：
de Latour, Regis Peffault;Purtill, Duncan;Rocha, Vanderson
关于严重再生障碍性贫血 (SAA) 患者无关脐带血移植 (UCBT) 后结果的信息很少。我们回顾性分析了 1996 年至 2009 年间在 32 个中心接受单单位 (n = 57; 79%) 或双单位 UCBT (n = 14; 19%) 的 71 名 SAA 患者（中位年龄 13 岁；28 名成人）（9 名患有阵发性睡眠性血红蛋白尿 [PNH]）。 68%的患者。第 60 天时中性粒细胞恢复的累积发生率 (Cl) 为 51% +/- 6%，在较高预冻总有核细胞 (TNC) 剂量的受者中观察到明显更好的植入（>3.9 10(7)/kg；风险比 [HR]，1.5；P = .05）。移植后第180天血小板植入的CI为37%+/-7%，II-IV级急性GVHD的CI为20%+/-5%，3年慢性GVHD的CI为18%+/-5%。中位随访 35 个月（范围 3-83 个月）时，3 年总生存 (OS) 的估计概率为 38% +/- 6%。在 >3.9 10(7) TNCs/kg 预冻的接受者中观察到 OS 显着改善（45%，而预冻的接受者为 18%）
Information is scarce on outcomes after unrelated cord blood transplantation (UCBT) for patients with severe aplastic anemia (SAA). We retrospectively analyzed 71 patients (median age, 13 years; 28 adults) with SAA (9 with paroxysmal nocturnal hemoglobinuria [PNH]) who received a single-unit (n = 57; 79%) or double-unit UCBT (n = 14; 19%) in 32 centers between 1996 and 2009. A reduced-intensity conditioning regimen was provided in 68% of the patients. The cumulative incidence (Cl) of neutrophil recovery was 51% +/- 6% at day 60, with significantly better engraftment seen in recipients of higher prefreezing total nucleated cell (TNC) dose (>3.9 10(7)/kg; hazard ratio [HR], 1.5; P = .05). The Cl of platelet engraftment at day 180 posttransplantation was 37% +/- 7%, that of grade II-IV acute GVHD was 20% +/- 5%, and that of chronic GVHD at 3 years was 18% +/- 5%. At a median follow-up of 35 months (range, 3-83 months), the estimated probability of 3-year overall survival (OS) was 38% +/- 6%. Significantly improved OS was seen in recipients of >3.9 10(7) TNCs/kg prefreezing (45%, compared with 18% for recipients of