Disabled-1 is down-regulated in clinical breast cancer and regulates cell apoptosis through NF-κB/Bcl-2/caspase-9
Disabled-1 is down-regulated in clinical breast cancer and regulates cell apoptosis through NF-κB/Bcl-2/caspase-9
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Disabled-1在临床乳腺癌中下调并通过NF-κB/Bcl-2/caspase-9调节细胞凋亡
DOI：
10.1111/jcmm.14047
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发表时间：
2019-02-01
影响因子：
5.3
通讯作者：
Cui, Shu-Sen
中科院分区：
文献类型：
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作者：
Cao, Rang-Juan;Li, Kai;Cui, Shu-Sen
Disabled-1（Dab 1）是一种调节发育过程中神经元迁移和分层的衔接蛋白。然而，Dab 1在乳腺癌中的确切功能尚不清楚。在这项研究中，我们检测了Dab 1在38例乳腺癌石蜡切片，以及60对冷冻乳腺癌及其癌旁组织中的表达。我们的研究结果表明，Dab 1在乳腺癌中表达减少，其表达受损与三阴性乳腺癌表型、低分化以及淋巴结转移相关。在乳腺癌细胞系中的功能分析表明，Dab 1促进细胞凋亡，这至少部分地依赖于其对NF-κ B B/Bcl-2/caspase-9通路的调节。我们的研究有力地表明，Dab 1可能是一个潜在的肿瘤抑制基因在乳腺癌。
Disabled-1 (Dab1) is best known as an adaptor protein regulating neuron migration and lamination during development. However, the exact function of Dab1 in breast cancer is unknown. In this study, we examined the expression of Dab1 in 38 breast cancer paraffin sections, as well as 60 paired frozen breast cancer and their adjacent tissues. Our results showed that Dab1 was reduced in breast cancer, and its compromised expression correlated with triple negative breast cancer phenotype, poor differentiation, as well as lymph node metastasis. Functional analysis in breast cancer cell lines demonstrated that Dab1 promoted cell apoptosis, which, at least partially, depended on its regulation of NF-kappa B/Bcl-2/caspase-9 pathway. Our study strongly suggests that Dab1 may be a potential tumour suppressor gene in breast cancer.