Determination of gut bacterial metabolites in radiation exposed mice
Determination of gut bacterial metabolites in radiation exposed mice
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辐射暴露小鼠肠道细菌代谢物的测定
DOI：
10.1093/rpd/ncz094
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发表时间：
2019
影响因子：
1
通讯作者：
Yamanouchi Kanako
中科院分区：
文献类型：
--
作者：
Sakamoto Yamato;Tsujiguchi Takakiyo;Ito Koichi;Yamanouchi Kanako
肠道微生物菌群（GM）以各种方式影响人类健康，既有益又有害。近年来，由于其在治疗、保护剂和辐射暴露生物标志物方面的应用而引起人们的关注。在这项研究中，我们专注于尚未被报道与辐射暴露有关的有机酸;我们测量了0，2，4和8 Gy照射小鼠粪便中的pH值和有机酸含量。在各组中观察到一些有机酸的共同波动趋势，表明辐射暴露与有机酸波动之间存在相关性。0和2戈伊，4和8 Gy照射小鼠之间的乳酸波动相似。基于这一发现，我们认为乳酸也可能是一种受辐射影响很大的有机酸。
Gut microflora (GM) impacts human health in various ways, both beneficial and detrimental. Recently, it has attracted attention for its application in treatment, as protective agents, and as biomarkers in radiation exposure. In this study, we focused on organic acids that have not yet been reported to be related to radiation exposure; we measured the pH and organic acid content in the faeces of 0, 2, 4 and 8 Gy-irradiated mice. A common trend of fluctuation of some organic acids was observed in each group, suggesting a correlation between radiation exposure and organic acid fluctuation. Lactate fluctuation was similar between 0 and 2 Gy-, and 4 and 8 Gy-irradiated mice. Based on this finding, we suggest that lactate may also be an organic acid that is greatly affected by irradiation.