Personalized exposure assessment: promising approaches for human environmental health research.
Personalized exposure assessment: promising approaches for human environmental health research.
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个性化暴露评估：人类环境健康研究的有前途的方法。
DOI：
10.1289/ehp.7651
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发表时间：
2005-07
影响因子：
10.4
通讯作者：
Wilson, Samuel H
中科院分区：
文献类型：
--
作者：
Weis, Brenda K;Balshaw, David;Barr, John R;Brown, David;Ellisman, Mark;Lioy, Paul;Omenn, Gilbert;Potter, John D;Smith, Martyn T;Sohn, Lydia;Suk, William A;Sumner, Susan;Swenberg, James;Walt, David R;Watkins, Simon;Thompson, Claudia;Wilson, Samuel H
评估人类接触化学品、饮食和生活方式因素、传染性病原体和其他压力因素的新技术和方法为扩大人类健康调查范围和增进我们对环境接触与疾病之间关系的理解提供了机会。召开了一个环境暴露技术开发特设委员会，以确定用于环境健康研究的个性化暴露测量的新技术和方法。该委员会确定了一个测量外部（环境）和内部（生物）暴露以及评估影响暴露于环境因子可能性的人类行为的方法“工具箱”。这些方法使用环境传感器，地理信息系统，生物传感器，毒理基因组学和身体负担（生物）测量。我们讨论了每一种方法在人类健康研究中的当前使用，在开发，验证和应用的方法的具体差距突出。我们还提出了一个概念框架，将这些技术投入使用，并接受科学界。该框架的重点是了解复杂的人类疾病，采用综合方法进行接触评估，以确定特定的疾病-疾病关系以及疾病发生中遗传和环境因素的相互作用。改进的暴露评估方法将导致更好的监测手段和针对性的干预和预防方案。
New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human health investigations and advance our understanding of the relationship between environmental exposure and disease. An ad hoc Committee on Environmental Exposure Technology Development was convened to identify new technologies and methods for deriving personalized exposure measurements for application to environmental health studies. The committee identified a “toolbox” of methods for measuring external (environmental) and internal (biologic) exposure and assessing human behaviors that influence the likelihood of exposure to environmental agents. The methods use environmental sensors, geographic information systems, biologic sensors, toxicogenomics, and body burden (biologic) measurements. We discuss each of the methods in relation to current use in human health research; specific gaps in the development, validation, and application of the methods are highlighted. We also present a conceptual framework for moving these technologies into use and acceptance by the scientific community. The framework focuses on understanding complex human diseases using an integrated approach to exposure assessment to define particular exposure–disease relationships and the interaction of genetic and environmental factors in disease occurrence. Improved methods for exposure assessment will result in better means of monitoring and targeting intervention and prevention programs.