ASSOCIATION BETWEEN NONSPECIFIC BRONCHIAL HYPERREACTIVITY AND SUPEROXIDE ANION PRODUCTION BY POLYMORPHONUCLEAR LEUKOCYTES IN CHRONIC AIR-FLOW OBSTRUCTION
ASSOCIATION BETWEEN NONSPECIFIC BRONCHIAL HYPERREACTIVITY AND SUPEROXIDE ANION PRODUCTION BY POLYMORPHONUCLEAR LEUKOCYTES IN CHRONIC AIR-FLOW OBSTRUCTION
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DOI：
10.1164/ajrccm/137.1.57
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发表时间：
1988-01-01
期刊：
影响因子：
--
通讯作者：
KAUFFMAN, H
中科院分区：
文献类型：
--
作者：
POSTMA, DS;RENKEMA, TEJ;KAUFFMAN, H
炎症反应在非特异性支气管高反应性(BHR)中起重要作用。为探讨氧化剂对BHR的调节作用，我们对28例非过敏性慢性气流阻塞(CAO)患者外周血中多形核白细胞(PMN)的氧化代谢进行了研究。14例CAO吸烟者与14例既往吸烟者O2-浓度无明显差异。吸烟者和戒烟者经20 ng/ml佛波醇醋酸酯刺激后，BHR与PMN产生O2-呈显著正相关(r=0.59，p<；0.01)。根据实验动物研究的其他发现，这些结果表明O2-在BHR的调节中起着直接或间接的作用。因此，在非过敏性CAO患者中，BHR和炎症可能以类似于过敏性哮喘患者的方式联系在一起。
Inflammatory reactions are believed to be important in nonspecific bronchial hyperreactivity (BHR). To investigate the potential role for oxidant-mediated modulation of BHR, we investigated oxidative metabolism of polymorphonuclear leukocytes (PMN) from the peripheral blood in 28 nonallergic patients with chronic air-flow obstruction (CAO). No difference in O2- was found between 14 smokers and 14 ex-smokers with CAO. A significant correlation was found between the degree of BHR and O2--generation of PMN after stimulation with 20 ng/ml phorbol myristate acetate, both in smokers (r = 0.59, p < 0.01) and in ex-smokers (r = 0.79, p < 0.01). In the light of other findings in experimental animal studies, the results suggest a direct or indirect role for O2- in the modulation of BHR. Thus, in nonallergic patients with CAO, BHR and inflammation may be linked in a similar way as in allergic patients with asthma.