A master CLOCK hard at work brings rhythm to the transcriptome
A master CLOCK hard at work brings rhythm to the transcriptome
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DOI：
10.1101/gad.180984.111
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发表时间：
2011-11-15
影响因子：
10.5
通讯作者：
Edery, Isaac
中科院分区：
文献类型：
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作者：
Edery, Isaac
在这期《基因与发育》中，Abruzzi等人（第2374-2386页）使用染色质免疫沉淀（ChIP）平铺阵列测定（ChIP- ChIP）表明昼夜节律（与24小时一致）时钟机制和基因组之间的物理相互作用比以前认为的更为广泛，并为时钟如何驱动全球基因表达的日常节律提供了新的见解。
In this issue of Genes & Development, Abruzzi et al. (pp. 2374-2386) use chromatin immunoprecipitation (ChIP) tiling array assays (ChIP-chip) to show that physical interactions between circadian (congruent to 24-h) clock machineries and genomes are more widespread than previously thought and provide novel insights into how clocks drive daily rhythms in global gene expression.