Muscular contraction stimulates posterior hypothalamic neurons.
Muscular contraction stimulates posterior hypothalamic neurons.
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肌肉收缩刺激下丘脑后部神经元。
DOI：
10.1152/ajpregu.1989.256.2.r348
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Stremel,RW
中科院分区：
文献类型：
--
作者：
Waldrop,TG;Stremel,RW
最近的研究表明，下丘脑后部的下丘脑运动区（STLR）参与调节对收缩肌肉反馈的心肺反应。本研究的目的是确定该下丘脑区域的神经元在后肢肌肉收缩期间是否改变其放电频率。使用不锈钢电极记录麻醉猫后肢肌肉静态和节律收缩期间 STLR 神经元的单单位活动。还对丘脑底运动区周围区域的神经元进行了记录。通过刺激 L7 和 S1 腹根的外周切口诱导小腿三头肌收缩。小腿三头肌的静态和节律性收缩都会引起大多数研究的 STLR 细胞放电率的增加。观察到两种类型的兴奋反应：1）肌肉收缩开始时放电频率突然增加，2）放电频率延迟且逐渐增加。大多数对肌肉收缩做出反应的细胞可以通过小腿三头肌的机械探测来激活。然而，放电频率的变化与肌肉收缩期间发生的动脉压的变化无关。大多数位于 STLR 外部的神经元受到肌肉收缩的轻微抑制或没有反应。因此，收缩肌肉的输入主要对下丘脑后部的神经元产生兴奋作用。这些结果与其他研究一致，这些研究得出的结论是，下丘脑部位参与影响肌肉收缩的心肺反应。
Recent studies have suggested that the subthalamic locomotor region (STLR) of the posterior hypothalamus is involved in modulating cardiorespiratory responses to feedback from contracting muscles. The purpose of this study was to determine whether neurons in this hypothalamic region alter their discharge frequency during contraction of hindlimb muscles. Stainless steel electrodes were used to record single-unit activity of STLR neurons during static and rhythmic contractions of hindlimb muscles in anesthetized cats. Recordings were also made from neurons in areas outside but surrounding the subthalamic locomotor region. Contraction of the triceps surae muscles was induced by stimulation of the peripheral cut ends of the L7 and S1 ventral roots. Both static and rhythmic contractions of the triceps surae evoked an increase in the discharge rate of the majority of the STLR cells studied. Two types of excitatory responses were observed: 1) abrupt increases in discharge frequency at the onset of muscular contraction and 2) a delayed more gradual increase in firing. Most of the cells that responded to muscular contraction could be activated by mechanical probing of the triceps surae muscles. However, the changes in discharge frequency were unrelated to changes in arterial pressure occurring during muscular contraction. Most of the neurons located outside the STLR were slightly inhibited by or did not respond to muscular contraction. Thus input from contracting muscles exerts predominantly an excitatory effect on neurons in the posterior hypothalamus. These results are consistent with other studies which have concluded that this hypothalamic site is involved in influencing the cardiorespiratory responses to muscular contraction.