Experimental spinal cord trauma, I: Correlation of blood flow, tissue oxygen and neurologic status in the dog.
Experimental spinal cord trauma, I: Correlation of blood flow, tissue oxygen and neurologic status in the dog.
复制标题
实验性脊髓创伤，I：狗血流量、组织氧和神经状态的相关性。
作者：
T. Ducker;M. Salcman;P. Perot;D. Ballantine
在一系列截瘫犬的实验性脊髓损伤中，同时测量了脊髓血流量和组织氧。脊髓损伤足以导致临床截瘫，与损伤后2至3小时中央脊髓血流量从15.2至6.1ml/分钟/100克显著减少(P<0.01)有关。此外，在损伤后2小时和3小时，截瘫犬的组织氧水平显著下降(P<0.01)，从35-39毫米汞下降到17-24毫米汞。全身血压和颈动脉血流量无明显变化。延迟通常发生在血流和组织氧变化显著开始之前，这表明治疗努力可以在这个关键的间歇期进行指导。
Spinal cord blood flow and tissue oxygen were measured concurrently in a series of paraplegic dogs subjected to experimental spinal cord trauma. Injury to the spinal cord sufficient to cause clinical paraplegia is associated with a significant (P less than 0.01) decrease in blood flow in the central spinal cord from 15.2 to 6.1 ml/min/100gms at two to three hours following injury. Also, at two and three hours post-injury, paraplegic dogs demonstrate a significant (P less than 0.01) decrease in tissue oxygen levels from 35-39 mm Hg to 17-24 mm Hg. No significant changes occurred in systemic blood pressure or carotid blood flow. A delay often precedes the significant onset of blood flow and tissue oxygen alterations, which suggests that therapeutic efforts could be directed during this critical interval.