Prevention of wound sepsis in amputations by peri-operative antibiotic cover with an amoxycillin-clavulanic acid combination.
Prevention of wound sepsis in amputations by peri-operative antibiotic cover with an amoxycillin-clavulanic acid combination.
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通过围手术期使用阿莫西林-克拉维酸组合抗生素覆盖来预防截肢伤口败血症。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
N. Kritzinger
中科院分区：
文献类型：
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作者：
W. Huizinga;J. Robbs;N. Kritzinger
对44例下肢缺血因严重肢体败血症需要截肢的患者进行了一系列研究，比较了具有β -内酰胺酶抑制特性的新型抗生素阿莫西林加克拉维酸（a- ca） （Augmentin; Beecham）与青霉素在预防创面感染中的作用。围手术期A-CA组脓毒症发生率为12.9%，显著低于青霉素对照组的76.9% （x2 = 14,48; P < 0.001）。结论是，在这种情况下需要围手术期抗生素覆盖，并且a - ca似乎非常有效。在A-CA覆盖下，伤口主要闭合或保持开放的脓毒症的发展没有统计学差异。
In a series of 44 patients with lower limb ischaemia requiring amputation for major limb sepsis, the performance of a new antibiotic combination with beta-lactamase-inhibiting properties, amoxycillin plus clavulanic acid (A-CA) (Augmentin; Beecham), was compared with that of penicillin in the prevention of wound infection. The sepsis rate of 12,9% in the group of patients receiving peri-operative A-CA was significantly lower than the 76,9% in the penicillin control group (x2 = 14,48; P less than 0,001). It is concluded that there is a need for peri-operative antibiotic cover in this situation and that A-CA appears to be highly effective. No statistical difference was found as regards development of sepsis in wounds closed primarily or left open while under A-CA cover.