The "switch process" in manic-depressive illness. I. A systematic study of sequential behavioral changes.
The "switch process" in manic-depressive illness. I. A systematic study of sequential behavioral changes.
复制标题
躁狂抑郁症的“转换过程”。
作者：
W. Bunney;D. Murphy;F. Goodwin;G. Borge
本文介绍了一组躁狂抑郁症患者的“转换过程”的行为和生物学方面的三部分报告的第一部分。它记录了在10次从抑郁到躁狂的自发转换和7次从躁狂到抑郁的转换过程中观察到的思想和情绪变化的规律性时间模式。在这些变化期间，每8小时对患者进行一次详细描述，并对他们的行为进行纵向评估。在转换为躁狂之前的抑郁期以中度抑郁、隐居、不说话和打瞌睡为特征。10次躁狂发作中的每一次发作之前都有一个正常或过渡期，表现为突然出现自发性言语和运动活动以及情绪正常化。总睡眠时间在转换为躁狂的前一天明显减少，并在躁狂期间保持较低水平。
This paper presents the first of a three-part report on behavioral and biological aspects of the "switch process" in a group of manicdepressive patients. It documents a regular temporal pattern of change in thought and mood observed during ten spontaneous episodes of switches from depression into mania and seven episodes of switches out of mania into depression. Patients were described in detail and their behavior rated every eight hours on a longitudinal basis throughout these periods of change. The depressive period prior to the switch into mania was characterized by moderate depression, seclusiveness, nonverbalization, and dozing. Each of the ten episodes of mania was preceded by a normal or transitional period which was manifested by sudden appearance of spontaneous speech and motor activity and normalization of mood. Total sleep time was markedly reduced on the day prior to the switch into mania and remained low during the manic period.