The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high-resolution manometry and videofluoroscopy
The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high-resolution manometry and videofluoroscopy
复制标题
DOI：
10.1111/j.1365-2036.2006.03090.x
复制
发表时间：
2006-10-01
影响因子：
7.6
通讯作者：
Schwizer, W.
中科院分区：
文献类型：
--
作者：
Fox, M.;Menne, D.;Schwizer, W.
替加色罗是一种5-羟色胺4受体部分激动剂，具有促胃动力作用，但对食管功能的影响尚不清楚。与安慰剂相比（n = 17/21完成了研究的两个阶段）。在试验餐前后进行高分辨率测压和pH测量。结果与安慰剂相比，替加色罗对下食管括约肌压力无影响，蠕动速度增加（P < 0.001），远端收缩压略有下降（P < 0.05）。暂时性下食管括约肌松弛和反流不常见，无论治疗。在食团转运研究中，高分辨率测压显示替加色罗促进食管中段收缩力（P < 0.02）并缩短“近端过渡区”（P < 0.05），这是食团逃逸最常见的水平。结论替加色罗对食管下括约肌压力无明显影响，但对食管下括约肌蠕动功能有明显影响。高分辨率测压促进团注运输过程中食管中段收缩力。该效应与改善固体团注传输的非显著趋势相关。
Background Tegaserod is a partial 5-hydroxytryptamine 4 receptor agonist with prokinetic effects on the gastrointestinal tract, its effects on oesophageal function are unknown.Aim A randomized, placebo controlled, double-blind trial assessed the effect of tegaserod on the oesophagus in healthy, asymptomatic subjects.Method A 7-day course of tegaserod 6 mg b.d. vs. placebo was prescribed (n = 17/21 completed both phases of study). High-resolution manometry and pH measurements were performed before and after a test meal. Bolus transport of liquids and solids was studied by high-resolution manometry and videofluoroscopy.Results Tegaserod had no effect on lower oesophageal sphincter pressure compared with placebo, peristaltic velocity increased (P < 0.001) and distal contractile pressure decreased slightly (P < 0.05). Transient lower oesophageal sphincter relaxations and reflux were infrequent regardless of treatment. During the studies of bolus transport, high-resolution manometry revealed that tegaserod promoted mid-oesophageal contractility (P < 0.02) and shortened the 'proximal transition zone' (P < 0.05), the level where bolus escape occurred most frequently. These effects had no effect on liquid bolus transport; however a non-significant trend to improved solid bolus transport was observed (66% vs. 31%;P = 0.07).Conclusion Tegaserod did not alter lower oesophageal sphincter pressure, but had significant effects on peristaltic function. High-resolution manometry promoted mid-oesophageal contractility during bolus transport. This effect was associated with a non-significant trend to improved solid bolus transit.