Independent expansion of zincin metalloproteinases in Onygenales fungi may be associated with their pathogenicity.
Independent expansion of zincin metalloproteinases in Onygenales fungi may be associated with their pathogenicity.
复制标题
DOI：
10.1371/journal.pone.0090225
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang KQ
中科院分区：
文献类型：
--
作者：
Li J;Zhang KQ
为了全面了解真菌M35家族（deuterolysin）和M36家族（fungalysin）的基因，我们对50株不同生活方式的子囊菌门真菌进行了全基因组调查和系统发育分析。M35和M36家族基因的数量在不同真菌基因组中存在较大差异，表明这两个基因家族在真菌进化过程中具有高度的动态性。此外，我们发现Meps在两个家庭的Onygenales：Onygenaceae和Arthodermataceae明显的扩展，而家庭Aesthomycetace没有显示这些基因的扩展。甲藻目中基因重复和丢失模式的显著差异可能与不同种的致病性有关。有趣的是，M35家族和M36家族基因的似然比检验（LRT）表明，导致皮肤癣菌和球孢子菌属真菌中重复基因的几个分支具有正选择的特征，表明重复的Mep基因可能在功能上发生了分化，在皮肤癣菌和球孢子菌属真菌的致病性进化过程中发挥了重要作用。通过我们的分析发现的潜在的积极选择的残基可能有助于开发新的生理功能的重复Mep基因在皮肤真菌和球孢子菌属物种。我们的研究增加了真菌中Meps进化的现有知识，也为未来的实验研究奠定了理论基础。
To get a comprehensive view of fungal M35 family (deuterolysin) and M36 family (fungalysin) genes, we conducted genome-wide investigations and phylogenetic analyses of genes in these two families from 50 sequenced Ascomycota fungi with different life styles. Large variations in the number of M35 family and M36 family genes were found among different fungal genomes, indicating that these two gene families have been highly dynamic through fungal evolution. Moreover, we found obvious expansions of Meps in two families of Onygenales: Onygenaceae and Arthodermataceae, whereas species in family Ajellomycetace did not show expansion of these genes. The strikingly different gene duplication and loss patterns in Onygenales may be associated with the different pathogenicity of these species. Interestingly, likelihood ratio tests (LRT) of both M35 family and M36 family genes suggested that several branches leading to the duplicated genes in dermatophytic and Coccidioides fungi had signatures of positive selection, indicating that the duplicated Mep genes have likely diverged functionally to play important roles during the evolution of pathogenicity of dermatophytic and Coccidioides fungi. The potentially positively selected residues discovered by our analysis may have contributed to the development of new physiological functions of the duplicated Mep genes in dermatophytic fungi and Coccidioides species. Our study adds to the current knowledge of the evolution of Meps in fungi and also establishes a theoretical foundation for future experimental investigations.
登录
查看更多内容
影响因子：
3.5
作者：
Antolovic D;Galindo L;Carstens A;Rahbari N;Büchler MW;Weitz J;Koch M
通讯作者：
Koch M
DOI：
10.1186/bcr2131
发表时间：
2008
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Deng G;Herrler M;Burgess D;Manna E;Krag D;Burke JF
通讯作者：
Burke JF
影响因子：
6
作者：
Liu, Hongyan;Dong, Huijia;Liu, Chen
通讯作者：
Liu, Chen
影响因子：
11.5
作者：
Riethdorf, Sabine;Fritsche, Herbert;Pantel, Klaus
通讯作者：
Pantel, Klaus
影响因子：
50.5
作者：
Coumans, F. A. W.;Doggen, C. J. M.;Terstappen, L. W. M. M.
通讯作者：
Terstappen, L. W. M. M.