Head circumference in infants with non-opiate-induced neonatal abstinence syndrome
Head circumference in infants with non-opiate-induced neonatal abstinence syndrome
复制标题
非阿片类药物引起的新生儿戒断综合征婴儿的头围
DOI：
10.1017/s1092852920001522
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tsukahara H
中科院分区：
文献类型：
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作者：
Morimoto D;Washio Y;Hatayama K;Okamura T;Watanabe H;Yoshimoto J;Tsukahara H
背景 目前尚未报道非阿片类新生儿戒断综合征 (NAS) 与人体测量指数（包括头围 (HC)）之间的关系。本研究的目的是确定母亲使用非阿片类药物与 NAS 新生儿出生时 HC 之间的关系。 方法这项回顾性观察研究包括 2010 年 1 月 1 日至 2019 年 3 月 31 日期间出生的新生儿，其母亲曾服用抗精神病药、抗抑郁药、镇静剂或抗惊厥药物。结果指标是 NAS 婴儿和对照的 HC。结果 159 名婴儿中，33 名 (21%) 被诊断患有 NAS。母亲在怀孕期间没有使用阿片类药物。 NAS 组的 HC 明显小于对照组。 NAS 组和对照组出生时 HC 的中位 z 得分分别为 -0.20 和 0.29 (P = .011)。 NAS 组和对照组出生时的中位 HC 分别为 33.0 和 33.5 厘米。多变量分析显示，母亲抗精神病药物的使用和选择性血清素再摄取抑制剂与 NAS 独立相关（分别为 P < .001 和 P = .004）。值得注意的是，苯二氮卓类药物的使用和吸烟不是独立的危险因素。结论结果表明，母亲抗精神病药物的使用与 NAS 之间存在关联，这进一步与 HC 降低相关。应考虑仔细监测母亲的药物使用情况，以改善胎儿的结局。
BackgroundNo relationship has been reported between nonopiate neonatal abstinence syndrome (NAS) and anthropometric indices, including head circumference (HC). The purpose of this study was to determine the relationship between maternal nonopioid drug use and HC at birth in neonates with NAS.MethodsThis retrospective observational study included neonates born between January 1, 2010 and March 31, 2019, whose mothers had been taking antipsychotic, antidepressant, sedative, or anticonvulsant medications. The outcome measures were HCs of NAS infants and controls.ResultsOf 159 infants, 33 (21%) were diagnosed with NAS. There was no maternal opioid use among mothers during pregnancy. The HCs in the NAS group were significantly smaller than those in the control group. The median z-scores for HC at birth were −0.20 and 0.29 in the NAS group and the control group, respectively (P = .011). The median HCs at birth were 33.0 and 33.5 cm in the NAS group and the control group, respectively. Multivariate analysis revealed that maternal antipsychotic drug use and selective serotonin reuptake inhibitors were independently associated with NAS (P < .001 and P = .004, respectively). Notably, benzodiazepine use and smoking were not independent risk factors.ConclusionsThe results suggest an association between maternal antipsychotic drug use and NAS, which was further associated with decreased HC. Careful monitoring of maternal drug use should be considered to improve fetal outcomes.